{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:36:47Z","timestamp":1774928207686,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070357"],"award-info":[{"award-number":["82070357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between pulse pressure and long\u2010term mortality was investigated among acute coronary syndrome (ACS) patients who received percutaneous coronary intervention (PCI). The study population included 5055 ACS patients in the Department of Cardiology of Beijing Friendship Hospital who were enrolled from January 2013 to July 2019. The median duration of follow\u2010up was 24 months. Multivariate Cox regression was used to analyze the relationships between PP on inpatient admission and mortalities. Non\u2010linear associations were studied by\u00a0restricted\u00a0cubic\u00a0splines. Considering the heart function, the analyses were performed in the whole cohort and the LVEF\u00a0&gt;\u00a0=\u00a00.5 cohort separately. Subgroup analyses were performed according to the different diagnosis (the myocardial infarction subgroup and the unstable angina pectoris subgroup). When PP was used\u00a0as\u00a0categorical\u00a0variable, the high PP group (\u226561\u00a0mm Hg) significantly increased the risk of death compared with the intermediate PP group (50\u201360\u00a0mm Hg) in the both cohorts. When PP was used as continuous\u00a0variable,\u00a0a U\u2010shape relationship were found between PP and mortalities in the whole cohort (<jats:italic>p<\/jats:italic> (for nonlinearity)\u00a0=\u00a0.005 and .003, respectively), with reference PP level of 55\u00a0mm Hg. However, this U\u2010shape relationship disappeared in the LVEF\u00a0&gt;\u00a00.5 cohort (<jats:italic>p<\/jats:italic> (for nonlinearity)\u00a0=\u00a0.111 and .117, respectively). The similar results were obtained in MI subgroup. From this study, the U\u2010shape relationships between PP level and all\u2010cause and cardiac mortalities were found in ACS patients who underwent PCI. The U\u2010shape relationships disappeared in the LVEF\u00a0&gt;\u00a00.5 cohort. The reference PP level was 55\u00a0mm Hg.<\/jats:p>","DOI":"10.1111\/jch.14408","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T10:55:45Z","timestamp":1639047345000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The U\u2010shape relationship between pulse pressure level on inpatient admission and long\u2010term mortality in acute coronary syndrome patients undergoing percutaneous coronary intervention"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-5437","authenticated-orcid":false,"given":"Huang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Geriatrics and Gerontology Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hongwei","sequence":"additional","affiliation":[{"name":"Department of 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