{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:23:24Z","timestamp":1747185804903,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Majority of previous studies showed no association between a single health behavior and arterial stiffness, but the benefit of simultaneously having multiple healthy behaviors (optimal lifestyle) on the progression of arterial stiffness is unknown. Among 2810 individuals (age 60.0\u00a0\u00b1\u00a09.4, 46.5% male), optimal lifestyle marker (yes\/no) on four health behaviors (ie, BMI\u00a0&lt;\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>, never or former smoker, never or moderate drinker, exercised\u00a0&gt;\u00a0500 METS min\/week) across four visits (\u2248 5 years) were summed to create an optimal lifestyle score. Carotid arterial stiffness was measured using distensibility coefficient (DC) and Young's elastic modulus (YEM) at visit 1 and after a mean of 9.5 years (visit 5). The association of optimal lifestyle with 10\u2010year percent change in DC and YEM was assessed using multiple linear regression. DC decreased by 5.3% and YEM increased by 24.4% over 10\u00a0years. Mean optimal lifestyle score was 9.4\u00a0\u00b1\u00a03.1 (range: 0\u201316). Individuals in quintiles 2\u20135 of optimal lifestyle score compared to quintile 1 (with the least optimal lifestyle score) did not show slower deceleration of DC [Q2, \u22120.3% (95% CI: \u22126.0, 5.4); Q3, \u22120.01% (\u22124.5, 4.5); Q4, \u22120.6% (\u22125.2, 3.9); Q5, \u22120.4% (\u22125.3, 4.4)], trend <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.82] or slower progression of YEM [Q2, 0.1% (\u22127.1, 7.3); Q3, \u22120.8% (\u22128.0, 6.5); Q4, 4.5% (\u22122.3, 11.3); Q5, \u22120.2% (\u22128.3, 7.9)], trend <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.49] after adjusting for risk factors. The association remained non\u2010significant when stratified by categories of age, sex, race, BP control, and diabetes. Our findings indicate that optimal score on multiple health behaviors may not independently slow arterial stiffness progression.<\/jats:p>","DOI":"10.1111\/jch.14430","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T09:44:57Z","timestamp":1644313497000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimal lifestyle behaviors and 10\u2010year progression of arterial stiffness: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-547X","authenticated-orcid":false,"given":"Yacob G.","family":"Tedla","sequence":"first","affiliation":[{"name":"Division of Epidemiology Department of Medicine Vanderbilt University Medical Center  Madison Wisconsin 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