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The side effect could lead to dose reduction or discontinuation of the medication. The combination of DHPCCBs and renin\u2010angiotensin system blockers has shown to reduce the risk of DHPCCBs\u2010associated peripheral edema compared with DHPCCBs monotherapy. We performed the current systematic review and network meta\u2010analysis of randomized controlled trials (RCTs) to estimate the rate of peripheral edema with DHPCCBs as a class and with individual DHPCCBs and the ranking of the reduction of peripheral edema. The effects of renin\u2010angiotensin system blockers on DHPCCBs network meta\u2010analysis were created to analyze the ranking of the reduction of peripheral edema. A total of 3312 publications were identified and 71 studies with 56,283 patients were included. Nifedipine ranked highest in inducing peripheral edema (SUCRA 81.8%) and lacidipine (SUCRA 12.8%) ranked the least. All DHPCCBs except lacidipine resulted in higher relative risk (RR) of peripheral edema compared with placebo. Nifedipine plus angiotensin receptor blocker (SUCRA: 92.3%) did not mitigate peripheral edema and amlodipine plus angiotensin\u2010converting enzyme inhibitors (SUCRA: 16%) reduced peripheral edema the most. Nifedipine ranked the highest and lacidipine ranked the lowest amongst DHPCCBs for developing peripheral edema when used for cardiovascular indications. The second or higher generation of DHPCCBs combination with ACEIs or ARBs or diuretics lowered the chance of peripheral edema development compared to single DHPCCB treatment.<\/jats:p>","DOI":"10.1111\/jch.14436","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T06:59:51Z","timestamp":1646204391000},"page":"536-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Comparative peripheral edema for dihydropyridines calcium channel blockers treatment: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ling","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Xiamen University, School of Medicin, Xiamen University  Xiamen China"},{"name":"Department of Cardiology the Third Clinical Medical College, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice Y.","family":"Kung","sequence":"additional","affiliation":[{"name":"University of Alberta John W. 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