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However, current guidelines do not recommend a reasonable diagnostic threshold of uPCR for severe preeclampsia with renal damage. Furthermore, the correlation between the uPCR value and clinical adverse outcomes remains poorly understood. The aim of the present study was to evaluate the value of uPCR in the diagnosis of significant proteinuria and to assess its correlation with adverse pregnancy outcomes in preeclampsia characterized by renal damage. In all, 1837 women were enrolled in this retrospective cohort study. Eventually, 961 women were enrolled under the exclusion criteria. First, the authors found that uPCR and 24\u2010hour proteinuria showed a significant association (r\u00a0=\u00a00.901). The optimal threshold of uPCR for diagnosing preeclampsia was 0.295, and for diagnosing severe preeclampsia the cut\u2010off was 0.625. Meanwhile, the adjusted odds ratio per 1 unit increase in ln (uPCR) was 1.679 (95% confidence interval [CI]:1.142\u20132.469) for severe adverse perinatal outcomes; 1.456 (95% CI: 1.242\u20131.705) for small for gestational age; 1.380 (95% CI: 1.051\u20131.811) for severe small for gestational age; 1.672 (95% CI: 1.210\u20132.310) for very early preterm birth; 1.989 (95% CI 1.726\u20132.293) for severe hypertension; and 2.279 (95% CI 1.906\u20132.724) for preterm birth. This study indicated that there was a significant and positive correlation between uPCR and 24\u2010hour urine protein. For neonatal and maternal adverse outcomes, uPCR is an independent predictor of prognosis.<\/jats:p>","DOI":"10.1111\/jch.14467","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:52:45Z","timestamp":1648223565000},"page":"652-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnosis of proteinuria using a random urine protein\u2010creatinine ratio and its correlation with adverse outcomes in pregnancy with preeclampsia characterized by renal damage"],"prefix":"10.1111","volume":"24","author":[{"given":"Jiangbo","family":"Xiao","sequence":"first","affiliation":[{"name":"Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing  Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Fan","sequence":"additional","affiliation":[{"name":"Women's Hospital of Nanjing Medical University 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