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A total of 12 693 patients who were prescribed a generic or brand\u2010name nifedipine between January 1, 2011, and December 31, 2018, were identified from the Chang Gung Research Database of Chang Gung Memorial Hospitals, Taiwan. Among them, 2112 (21.4%) were prescribed generic nifedipine. After propensity score matching, both the generic and brand\u2010name groups consisted of 2102 patients. At a mean follow\u2010up of 3 years, the changes in office systolic (<jats:italic>p<\/jats:italic> for interaction\u00a0=\u00a0.791) and diastolic blood pressure (<jats:italic>p<\/jats:italic> for interaction\u00a0=\u00a0.689) did not differ significantly between the patients who received the generic and the brand\u2010name nifedipine. There was no significant difference between the two study groups regarding the composite of all\u2010cause mortality, acute myocardial infarction, stroke, coronary revascularization, or hospitalization for heart failure (hazard ratio 0.98, 95% confidence interval 0.85\u20131.13; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.774). In conclusion, the generic nifedipine was comparable to its brand\u2010name counterpart regarding office blood pressure reduction and the composite cardiovascular outcome for the treatment of patients with hypertension.<\/jats:p>","DOI":"10.1111\/jch.14478","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T07:47:26Z","timestamp":1649231246000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative effectiveness of generic nifedipine versus Adalat long\u2010acting nifedipine for hypertension treatment: A multi\u2010institutional cohort study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-1472","authenticated-orcid":false,"given":"Ying\u2010Chang","family":"Tung","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University College 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