{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:50:34Z","timestamp":1790995834861,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The design and baseline data of the PRECISION study, which evaluates the effect of the dual endothelin receptor antagonist aprocitentan on blood pressure (BP) in patients with resistant hypertension (RHT) are presented. The study is a blinded, randomized, parallel\u2010group Phase 3 study and its three\u2010part design assesses the short\u2010term and sustained long\u2010term effects of aprocitentan on BP. Results are expected in 2022.<\/jats:p>\n                  <jats:p>Patients with uncontrolled BP (measured as unattended automated office BP) despite the use of three or more antihypertensive medications for at least 1 year were screened. They were switched to a single\u2010tablet triple fixed combination antihypertensive therapy for at least 4\u00a0weeks before entering a single\u2010blind placebo run\u2010in period. The 4\u2010week placebo run\u2010in period further excluded placebo responders. The randomization period consisted of three sequential parts: (1) a 4\u2010week double\u2010blind part with aprocitentan 12.5\u00a0mg, 25\u00a0mg, or placebo (1:1:1 ratio); (2) a 32\u2010week single\u2010blind part with aprocitentan 25\u00a0mg; and (3) a 12\u2010week randomized withdrawal part with aprocitentan 25\u00a0mg or placebo (1:1 ratio). The purpose was to demonstrate the BP lowering effect of aprocitentan in RHT (Part 1) and the persistence of this effect (Parts 2 and 3).<\/jats:p>\n                  <jats:p>Out of 1965 screened patients, 730 were randomized resulting in an overall inclusion failure rate of 62.8%. The most common reason for exclusion (44.4% of all screened patients) was failure to meet the BP inclusion criteria. These results underline the high proportion of pseudoresistant hypertension among patients referred for RHT.<\/jats:p>","DOI":"10.1111\/jch.14517","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T02:50:45Z","timestamp":1654829445000},"page":"804-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Identifying and treating resistant hypertension in PRECISION: A randomized long\u2010term clinical trial with aprocitentan"],"prefix":"10.1111","volume":"24","author":[{"given":"Parisa","family":"Danaietash","sequence":"first","affiliation":[{"name":"Idorsia Pharmaceuticals Ltd.  Allschwil Basel\u2010Landschaft Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Verweij","sequence":"additional","affiliation":[{"name":"Idorsia Pharmaceuticals Ltd.  Allschwil Basel\u2010Landschaft Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1524","authenticated-orcid":false,"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Rui Jin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dresser","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre \u2010 Victoria Hospital  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Kantola","sequence":"additional","affiliation":[{"name":"Division of Medicine Turku University Central Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Katherine","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Carteret Medical Group  Morehead City North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Narkiewicz","sequence":"additional","affiliation":[{"name":"Medical University of Gda\u0144sk  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-0195","authenticated-orcid":false,"given":"Markus","family":"Schlaich","sequence":"additional","affiliation":[{"name":"Dobney Hypertension Centre, Departments of Cardiology and Nephrology Royal Perth Hospital Unit \u2010 University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-6951","authenticated-orcid":false,"given":"Marc","family":"Bellet","sequence":"additional","affiliation":[{"name":"Idorsia Pharmaceuticals Ltd.  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