{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T05:30:27Z","timestamp":1772861427770,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The calcium channel blockers brand\u2010name amlodipine and nifedipine with extended\u2010release formulations demonstrate similar clinical efficacy. However, the efficacy of generic nifedipine remains obscure. We compared the efficacy of generic nifedipine and brand\u2010name amlodipine in terms of cardiovascular (CV) outcomes. Patients prescribed generic nifedipine (SRFC CYH) or brand\u2010name amlodipine besylate (Norvasc, Pfizer) between August 1, 2017, and July 31, 2018, were enrolled; patients with CV events within 3 months were excluded. CV outcomes included CV death, nonfatal myocardial infarction (MI), nonfatal ischemic stroke, hospitalization for heart failure, and composite endpoints of 3P\u2010 and 4P\u2010major adverse cardiac events (MACE). <jats:bold>A<\/jats:bold> total of 1625 patients treated with nifedipine (SRFC CYH) and 16 587 patients treated with Norvasc were included. After propensity score matching, there were 995 and 4975 patients in the nifedipine CYH and Norvasc groups, respectively. At a mean follow\u2010up period of 30.3 \u00b1 6.4 months, nifedipine CYH was comparable to Norvasc in terms of CV death (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.107), nonfatal MI (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.121), nonfatal ischemic stroke (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.453), hospitalization for heart failure (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.330), 3P\u2010MACE (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.584), and 4P\u2010MACE (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.274). Cox regression analysis revealed that nifedipine CYH and Norvasc had similar efficacy in terms of 3P\u2010MACE (hazard ratio, 0.970; 95% confidence interval, 0.601\u20131.565, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.900) and 4P\u2010MACE (hazard ratio, 0.880; 95% confidence interval, 0.628\u20131.233, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.459). In conclusion, Nifedipine SRFC CYH and Norvasc have comparable clinical efficacy for hypertension management.<\/jats:p>","DOI":"10.1111\/jch.14521","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T10:28:45Z","timestamp":1654684125000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative efficacy of generic nifedipine versus brand\u2010name amlodipine for hypertension management in Taiwan"],"prefix":"10.1111","volume":"24","author":[{"given":"Hao\u2010Wei","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-8734","authenticated-orcid":false,"given":"Chin\u2010Chou","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Pharmacology School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Bang","family":"Leu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Healthcare and Services Center Taipei Veterans General Hospital  Taipei 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