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The authors included 7217 normal\u2010weight and overweight individuals with normal cardiometabolic profiles from the 2001 to 2014 US National Health and Nutrition Examination Survey. The authors summarized demographic characteristics, cardiometabolic profiles, and behavioral factors across waist circumference quartiles. Then, in the logistic regression analysis, the authors observed a positive and significant association between waist circumference (as a continuous variable) and the prevalence of hypertension in all three models (nonadjusted, minimally adjusted, and fully adjusted), with odds ratios (95% confidence intervals) of 1.76 (1.65\u20131.86), 1.29 (1.20\u20131.39), and 1.24 (1.09\u20131.40), respectively. When analyzed as a categorical variable, individuals in the highest waist circumference group had a 1.48\u2010fold increased risk of hypertension than the lowest group in the fully adjusted model. Moreover, the Cox regression analysis revealed a positive and significant association between waist circumference and all\u2010cause mortality in individuals with hypertension in the nonadjusted model (HR, 1.27; 95% CI, 1.10\u20131.47) and the fully adjusted model (HR, 1.59; 95% CI, 1.22\u20132.06). In conclusions, our results showed that, even in those with normal metabolic profiles, high waist circumference was significantly associated with the increased prevalence of hypertension. And once hypertension has been established, patients with high waist circumference showed elevated all\u2010cause mortality. Therefore, waist circumference should be routinely measured and controlled regardless of metabolic profiles.<\/jats:p>","DOI":"10.1111\/jch.14528","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T03:09:25Z","timestamp":1656040165000},"page":"908-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High waist circumference is a risk factor for hypertension in normal\u2010weight or overweight individuals with normal metabolic profiles"],"prefix":"10.1111","volume":"24","author":[{"given":"Chen","family":"Cheng","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Gusu School Nanjing Medical University  Suzhou Jiangsu China"},{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University  Nanjing Jiangsu 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