{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:59:13Z","timestamp":1788328753411,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary Sj\u00f6gren's syndrome (pSS) patients with hypertension (pSS\u2010HT) have a significantly increased risk of cardio\u2010cerebrovascular events. Serum uric acid (SUA), a potential inflammatory substance, is considered to be closely related to hypertension in the general population. Our aim is to assess the association between SUA and pSS\u2010HT. This is a retrospective cohort study. The diagnosis of pSS is based on the American European Consensus Classification criteria. Primary outcome was incident hypertension in pSS patients. Cox regression model was used to estimate the hazard ratios (HR) and 95% CI of SUA in pSS\u2010HT. The authors also plotted Kaplan\u2013Meier plots to assess the cumulative risk of first hypertension in patients with hyperuricemia and normal uric acid. In addition, the dose\u2010response curve was also used to discuss the relationship between SUA and pSS\u2010HT. Finally, three hundred and fifty\u2010one pSS patients were enrolled from May 2011 to May 2020, of which 166 cases developed hypertension within a mean follow\u2010up of 3.91 years. Univariate Cox regression demonstrated that SUA was associated with the onset of hypertension in pSS (HR: 1.005 95%Cl: 1.002\u20131.009). After adjusting for the potential risk factors, the relationship remained unchanged (HR: 1.003, 95%Cl: 1.001\u20131.005). Kaplan\u2010Meier survival analysis showed a statistically significant difference of hypertension risk between hyperuricemia patients and normal uric acid patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026). There was also a significant dose\u2010effect relationship between SUA and hypertension in pSS in dose\u2010response model. In this study, the authors find that SUA may be closely associated with the development of hypertension in pSS, which is also confirmed by our dose\u2010response model. Therefore, SUA could be considered in the management of pSS\u2010HT.<\/jats:p>","DOI":"10.1111\/jch.14541","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T15:33:40Z","timestamp":1657380820000},"page":"1026-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationship between serum uric acid and hypertension in patients with primary Sj\u00f6gren's syndrome: A retrospective cohort study"],"prefix":"10.1111","volume":"24","author":[{"given":"Qiang","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Southwest Jiaotong University The Third People's 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