{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:48:22Z","timestamp":1780393702031,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Childhood hypertension has become a global public health issue due to its increasing prevalence and association with cerebral\u2010cardiovascular disease in adults. In this study, we developed a predictive model for childhood hypertension based on environmental and genetic factors to identify at\u2010risk individuals. Eighty children diagnosed with childhood hypertension and 84 children in the control group matched by sex and age from an established cohort were included in a nested case\u2013control study. We constructed a multiple logistic regression model to analyze the factors associated with hypertension and applied the 10\u2010fold cross\u2010validation method to verify the prediction stability of the model. Childhood hypertension was found positively correlated with triglyceride level \u2265150\u00a0mg\/dL; low\u2010density lipoprotein cholesterol level \u2265110\u00a0mg\/dL; body mass index Z score; waist\u2010to\u2010height ratio Z score; and red\u00a0blood\u00a0cell count (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and negatively correlated with the relative expression level of retinol acyltransferase; relative expression level of vitamin D receptor; and dietary intake of fiber, vitamin C and copper (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) in this study. BMI Z score, triglyceride \u2265150\u00a0mg\/dL, RBC count, VDR\/\u03b2\u2010actin and LRAT\/\u03b2\u2010actin ratios were used to construct the predictive model. The area under the receiver operating characteristic curve was 94.45% (95% CI\u00a0=\u00a089.35%\u223c98.65%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were all above 80% in both the training and validation sets. In conclusion, this model can predict the risk of childhood hypertension and could provide a theoretical basis for early prevention and intervention to improve the cardiovascular health of children.<\/jats:p>","DOI":"10.1111\/jch.14544","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:42:48Z","timestamp":1658472168000},"page":"1015-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combining multiaspect factors to predict the risk of childhood hypertension incidence"],"prefix":"10.1111","volume":"24","author":[{"given":"Jishuang","family":"Tong","sequence":"first","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhou","family":"An","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Department Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qu","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Tang","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-9779","authenticated-orcid":false,"given":"Xiaohua","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Department Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders Key Laboratory of Pediatrics in Chongqing China International Science and Technology Cooperation Center of Child Development and Critical Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01374"},{"issue":"5","key":"e_1_2_8_3_1","first-page":"428","article-title":"Updating blood pressure references for Chinese children aged 3\u201317 years","volume":"25","author":"Fan H","year":"2017","journal-title":"Chin J Hypertens."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13512"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0366-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001242"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14156"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.730366"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067370"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187240"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13818"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-019-0282-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01245-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_685_20"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.04.036"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.09.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000439"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970715)16:13<1529::AID-SIM565>3.0.CO;2-H"},{"issue":"23","key":"e_1_2_8_19_1","first-page":"4835","article-title":"LiqiangQin. Evaluation of balanced diet pagodas in Chinese residents (2007)","volume":"38","author":"Zhiwei Wu JD","year":"2011","journal-title":"Modern Prev Med."},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee","volume":"854","year":"1995","journal-title":"World Health Organ Tech Rep Ser."},{"key":"e_1_2_8_21_1","volume-title":"Chinese food composition chart 2004","author":"Yang Y","year":"2005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.160"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.107012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0422-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169251"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.34.134.18309"},{"issue":"2","key":"e_1_2_8_28_1","first-page":"10","article-title":"Biochemical Markers and Hypertension in Children","volume":"21","author":"Gari\u2010Llanes M","year":"2019","journal-title":"MEDICC Rev."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210591"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010112"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.91176"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2012.645335"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933402"},{"key":"e_1_2_8_34_1","first-page":"80","volume-title":"Red cell distribution width and inflammation in patients with non\u2010dipper hypertension","author":"Ozcan F","year":"2013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2021.0113"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01118"},{"issue":"20","key":"e_1_2_8_37_1","first-page":"9066","article-title":"The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta\u2010analysis","volume":"23","author":"Zhu YB","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201910_19309"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03971"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1252"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215219"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.22729"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2020.1833023"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9295147"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120302793"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-234310"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes5030425"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4940673"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024545"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S83144"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019274"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246304"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.045102"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1391"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv034"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800141"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14427"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.6.H2884"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.14544","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:25:51Z","timestamp":1697073951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jch.14544"],"URL":"https:\/\/doi.org\/10.1111\/jch.14544","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2022-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}