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These drugs can be used in almost all hypertensive patients for blood pressure control. However, there are several special indications. Benign prostatic hyperplasia is a compelling indication of \u03b11\u2010blockers, because of the dual treatment effect on both high blood pressure and lower urinary tract symptoms. Many patients with resistant hypertension would require \u03b11\u2010blockers as add\u2010on therapy. Primary aldosteronism screen is a rapidly increasing clinical demand in the management of hypertension, where \u03b11\u2010blockers are useful for blood pressure control in the preparation for the measurement of plasma aldosterone and renin. Nonetheless, \u03b11\u2010blockers have to be used under several considerations. Among the currently available agents, only long\u2010acting \u03b11\u2010blockers, such as doxazosin gastrointestinal therapeutic system 4\u20138\u00a0mg daily and terazosin 2\u20134\u00a0mg daily, should be chosen. Orthostatic hypotension is a concern with the use of \u03b11\u2010blockers especially in the elderly, and requires careful initial bedtime dosing and avoiding overdosing. Fluid retention is potentially also a concern, which may be overcome by combining an \u03b11\u2010blocker with a diuretic.<\/jats:p>","DOI":"10.1111\/jch.14556","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T05:58:21Z","timestamp":1664949501000},"page":"1180-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Role of \u03b11\u2010blockers in the current management of hypertension"],"prefix":"10.1111","volume":"24","author":[{"given":"Hua","family":"Li","sequence":"first","affiliation":[{"name":"The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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