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Type 2 diabetes and hypertension overlap in the population. The present study investigated effects of smoking on glucose metabolism under different blood pressure (BP) levels in occupational population. A smoking survey among occupational groups was conducted in 2018. The general linear model was used to analyze the differences of glucose metabolism indexes and BP indexes influenced by different smoking intensity (never 0, mild &lt;10, moderate &lt;20, heavy \u226520 pack\u2010years). Odds ratios of developing diabetes and \u03b2\u2010cell deficiency were analyzed by using logistic regression model. BP was further taken into account in the relationship between smoking and glucose metabolism. As a result, 1730 male workers aged 21 to 60 years were included in the analysis finally. Compared to never smokers, heavy smokers had significantly increased fasting plasma glucose. Moderate and above smokers had significantly increased glycosylated hemoglobin, decreased fasting plasma insulin and \u03b2\u2010cell function, after adjustment for covariates. Further, smoking intensity was found to have a dose\u2010dependent relationship with impaired \u03b2\u2010cell function and diabetes. In conclusion, smoking has a positive dose\u2010dependent relationship with \u03b2\u2010cell deficiency and diabetes. Male smoking workers, especially the moderate or higher smoking, with high\u2010normal and high BP levels are at high risk of abnormal glucose metabolism.<\/jats:p>","DOI":"10.1111\/jch.14557","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T09:33:49Z","timestamp":1660037629000},"page":"1276-1284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Smoking causes the disorder of glucose metabolism under different levels of blood pressure in male occupational population"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-9617","authenticated-orcid":false,"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deren","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Chronic Non\u2010communicable Disease Control Wujin District Center for Disease Control and Prevention  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chronic Non\u2010communicable Disease Control Changzhou Center for Disease Control and Prevention  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-3682","authenticated-orcid":false,"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-8540","authenticated-orcid":false,"given":"Yu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Chronic Non\u2010communicable Disease Control Jiangsu Provincial Center for Disease Control and Prevention  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chronic Non\u2010communicable Disease Control Jiangsu Provincial Center for Disease Control and Prevention  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Global Health The Key Laboratory of Modern Toxicology School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanyong","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Public Health Southeast University  Nanjing China"},{"name":"Department of Chronic Non\u2010communicable Disease Control Jiangsu Provincial Center for Disease Control and Prevention  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.7.891"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30407-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32366-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00340-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56014-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30026-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-1-201001050-00005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00316-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci17-0026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60987-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314487"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192653"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/841768"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30230-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.17660\/ActaHortic.2007.744.1"},{"key":"e_1_2_8_18_1","first-page":"10","article-title":"Bureau of Disease Prevention and Control, National Health Commission of People\u2032s Republic of China; National Center for Cardiovascular Diseases; Chinese Academy of Medical Science & Peking Union Medical College, Fuwai Hospital; et\u00a0al. 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