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In most prospective investigations, elevated central and peripheral BPs were similarly associated with adverse outcomes. Outcome\u2010driven thresholds of the central systolic BP estimated by the type I device were on average 10\u00a0mmHg lower than their brachial counterparts. Cross\u2010classification based on the central and brachial BPs identified that nearly 10% of patients had discrepancy in their status of central and brachial hypertension. Irrespective of the brachial BP status, central hypertension was associated with increased cardiovascular risk, highlighting the importance of central BP assessment in the management of hypertensive patients. Newer antihypertensive agents, such as renin\u2013angiotensin\u2013aldosterone system inhibitors and calcium channel blockers, were more efficacious than older agents in central BP reduction. Clinical trials are warranted to demonstrate whether controlling central hypertension with an optimized antihypertensive drug treatment will be beneficial beyond the control of brachial hypertension.<\/jats:p>","DOI":"10.1111\/jch.14561","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T05:58:21Z","timestamp":1664949501000},"page":"1174-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Central hypertension is a non\u2010negligible cardiovascular risk factor"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-3504","authenticated-orcid":false,"given":"Yi\u2010Bang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Shanghai Key Laboratory of Hypertension The Shanghai Institute of Hypertension State Key Laboratory of Medical Genomics National Research Centre for Translational Medicine Ruijin 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