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A nomogram of arterial stiffness was evaluated by calculation of ASI nomogram. Theoretical ASI can be performed according to age, sex, mean blood pressure, and heart rate, allowing to form an individual ASI nomogram [(measured ASI \u2013 theoretical ASI)\/theoretical ASI]. An ASI nomogram\u00a0&gt;\u00a00 defined AS. This study investigates among UK Biobank participants without cardiovascular diseases, the hypothesis that K\u2010means cluster analysis can be used to identify homogeneous phenotyping subgroups of participants according to ASI levels and then, the phenotype differences observed between these clusters. ASI nomogram was applied on 132\u00a0851 participants. K\u2010means clustering was implemented with 10 clusters (optimal CCC value of 105.246). One cluster showed 100% rate of AS, corresponding to 25\u00a0393 participants (41.6% of the AS participants) with ASI nomogram\u00a0=\u00a0.26 (.22), ASI\u00a0=\u00a011.6 (2.3)m\/s. A second cluster showed a 100% of non\u2010AS, corresponding to 27\u00a0844 participants (38.8% of the participants with no arterial stiffness) with ASI nomogram\u00a0=\u00a0\u2010.22 (.13), ASI\u00a0=\u00a07.1 (1.44)m\/s. Threshold values of independent factors for differencing these two clusters were total cholesterol\u00a0&gt;\u00a05.409\u00a0mmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), triglycerides\u00a0&gt;\u00a01.286\u00a0mmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), smoking pack years\u00a0&gt;\u00a011.8 pack\/years, CRP\u00a0&gt;\u00a0.99 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), daily alcohol consumption\u00a0&gt;\u00a01.794 units\/days and BMI\u00a0&gt;\u00a026.641\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Cluster analysis allowed to highlight homogeneous participants profile with or without AS. Determine the markers differencing these clusters participates in the management of cardiovascular preventive strategies.<\/jats:p>","DOI":"10.1111\/jch.14571","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T07:39:37Z","timestamp":1664955577000},"page":"1415-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Arterial stiffness nomogram identification by cluster analysis: A new approach of vascular phenotype modeling"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-4467","authenticated-orcid":false,"given":"Alexandre","family":"Vall\u00e9e","sequence":"first","affiliation":[{"name":"Department of Epidemiology\u2010Data\u2010Biostatistics Delegation of Clinical Research and Innovation (DRCI) Foch hospital  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236599.91051.1e"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.063"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007621"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-007-0010-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02350-6"},{"key":"e_1_2_9_7_1","first-page":"1257","article-title":"Arterial stiffness association with chronic inflammatory disorders in the UK Biobank study","volume":"104","author":"Dregan A","year":"2018","journal-title":"Heart Br Card Soc"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.156950"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-1006-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.897805"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.05.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030371"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13662"},{"key":"e_1_2_9_15_1","volume-title":"McDonald's Blood Flow in Arteries Theoretical, Experimental and Clinical Principles","author":"Nichols W","year":"2006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092512"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.03.098"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00035210"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.979"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.675558"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.08.038"},{"key":"e_1_2_9_24_1","unstructured":"UK Biobank.Arterial Pulse\u2010Wave Velocity. 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