{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:25:08Z","timestamp":1782321908436,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Orthostatic hypotension (OH) is a common autonomic disorder. This study aimed to investigate the influencing factors and hemodynamic mechanisms of initial and sustained OH in middle\u2010aged and elderly patients. The authors analyzed the clinical characteristics and hemodynamic variables of patients aged \u2265 50\u00a0years according to the various forms of OH, diagnosed by an active orthostatic test using the CNAP monitor. The study included 473 participants; 119 (25.2%) patients had initial (54, 45.4%) or sustained (65, 54.6%) OH. Age, comorbidities, or medications did not differ significantly between the initial OH and non\u2010OH groups. Sustained OH was associated with age and diabetes (<jats:italic>p<\/jats:italic> =\u00a0.003 and <jats:italic>p<\/jats:italic> =\u00a0.015, respectively). Hemodynamic analysis revealed higher cardiac output (CO) in the sustained OH group within 15 s than in the non\u2010OH and initial OH groups (both <jats:italic>p<\/jats:italic> &lt;\u00a0.001); no difference in CO was observed between the initial OH and non\u2010OH groups. The systemic vascular resistance (SVR) in both initial OH and sustained OH groups within 15 s was lower than that in the non\u2010OH group (both <jats:italic>p<\/jats:italic> &lt;\u00a0.001). No differences in SVR at 3\u00a0min were observed between the initial OH and non\u2010OH groups. The SVR at 3\u00a0min in the sustained OH group was significantly lower than in non\u2010OH and initial OH groups (both <jats:italic>p<\/jats:italic> &lt;\u00a0.001). Age and diabetes emerged as the independent risk factors associated with sustained OH. Initial OH is associated with a mismatch of increase in CO and decrease in SVR. Sustained OH is mainly associated with sustained inadequate adjustment in SVR.<\/jats:p>","DOI":"10.1111\/jch.14588","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T06:55:34Z","timestamp":1666248934000},"page":"1491-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influencing factors and hemodynamic study of initial and sustained orthostatic hypotension in middle\u2010aged and elderly patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-7933","authenticated-orcid":false,"given":"Geng","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Geriatrics Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xiahuan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Peking University First Hospital  Beijing 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