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A search was performed using PubMed, Web of Science, and Sciencedirect databases, supplemented by hand\u2010searching of related references. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated for each parameter. Twenty\u2010one studies involving 4197 patients with PA were included. Compared with bilateral PA groups, unilateral PA groups demonstrated significantly lower low\u2010density lipoprotein cholesterol (LDL\u2010C, SMD: \u2212.14\u00a0mmol\/L, 95% CI: \u2212.20, \u2212.07), total cholesterol (TC, SMD: \u2212.16\u00a0mmol\/L, 95% CI: \u2212.23, \u2212.09), triglyceride (TG, SMD: \u2212.22\u00a0mmol\/L, 95% CI: \u2212.29, \u2212.16), fasting blood glucose (FBG, SMD: \u2212.11\u00a0mmol\/L, 95% CI: \u2212.18, \u2212.04), hemoglobin A1c (HbA1c, SMD: \u2212.21%, 95% CI: \u2212.30, \u2212.13), and homeostasis model assessment\u2010insulin resistance (HOMA\u2010IR, SMD: \u2212.40, 95% CI: \u2212.58, \u2212.23). No significant difference was found in high\u2010density lipoprotein cholesterol (HDL\u2010C) level between the two groups (SMD: .40\u00a0mmol\/L, 95% CI: \u2212.02, .11). To sum up, comparison of several blood metabolic parameters between the two subtypes suggested that the bilateral PA may associate with a higher prevalence of impaired glucose and lipid metabolism than unilateral PA; however, results should be treated with caution. Additional well\u2010designed studies are needed to prove the present results and better elucidate the link between metabolic abnormalities and etiologies of each PA subtype.<\/jats:p>","DOI":"10.1111\/jch.14607","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T10:54:02Z","timestamp":1670583242000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Meta\u2010analysis of blood parameters related to lipid and glucose metabolism between two subtypes of primary aldosteronism"],"prefix":"10.1111","volume":"25","author":[{"given":"Qiu\u2010Gen","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Shanghai East Hospital Ji'an Hospital  Jian City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3409-7667","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Hospital of Jinggangshan University  Jian City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20104061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013\u20102805"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10263"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.101365"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000231338.41548.fc"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07\u20100525"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201010\u20101074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201015\u20100450"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122194"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101293"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010019\u201001114\u20106"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13582"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010018\u20100093\u20106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_16_1","volume-title":"JBI","author":"Moola S"},{"key":"e_1_2_8_17_1","unstructured":"HigginsJPT ThomasJ.Cochrane Handbook for Systematic Reviews of Interventions (Version 6.2). 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