{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:38Z","timestamp":1790740718451,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971126\/H0906"],"award-info":[{"award-number":["81971126\/H0906"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored the association between the serum level of cystatin C (CysC) at admission and short\u2010term functional outcome in patients with hypertensive intracerebral hemorrhage (HICH) without chronic kidney disease (CKD). A total of 555 patients with HICH were consecutively recruited after admission and were followed\u2010up for 3 months after admission. The primary outcome was poor functional outcome (modified Rankin Scale [mRS] score \u2265 3). The median serum CysC level in our cohort was 1.03 mg\/L (interquartile range, .89\u20131.20). Patients were categorized into four groups according to the serum CysC quartiles. Multivariate logistic regression analysis revealed a negative association between serum CysC and poor functional outcome at 3\u2010month follow\u2010up (quartile [Q]1 vs. Q4: adjusted odds ratio [OR] = .260, 95% confidence interval [CI] = .098, .691, <jats:italic>p<\/jats:italic> &lt; .001). The negative association between serum CysC and poor functional outcome at 3 months was more pronounced in subgroups with smaller hematoma volume (\u2264 30 mL), and absence of secondary intraventricular hemorrhage (IVH). Addition of serum CysC to a model containing conventional risk factors improved the model performance with net reclassification index (NRI) of .426% (<jats:italic>p<\/jats:italic> &lt; .001) and integrated discrimination improvement (IDI) of .043% (<jats:italic>p<\/jats:italic> &lt; .001) for poor functional outcome. Serum CysC was found to be a negative predictor of poor short\u2010term functional outcome in HICH patients independent of renal function.<\/jats:p>","DOI":"10.1111\/jch.14609","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T08:44:52Z","timestamp":1671698692000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lower serum cystatin C level predicts poor functional outcome in patients with hypertensive intracerebral hemorrhage independent of renal function"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-9614","authenticated-orcid":false,"given":"Yongfang","family":"Zhou","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Emergency Affiliated Hospital of Guizhou Medical University  Guiyang 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