{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:16:14Z","timestamp":1781756174343,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors performed a meta\u2010analysis to assess the efficacy of non\u2010atenolol \u03b2\u2010blockers as add\u2010on to monotherapy or as a component of combination antihypertensive therapy in patients with hypertension. The authors searched and identified relevant randomized controlled trials from PubMed until November 2021. Studies comparing blood pressure lowering effects of \u03b2\u2010blockers with diuretics, calcium channel blockers (CCBs), angiotensin\u2010converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs) were included. The analysis included 20 studies with 5544 participants. \u03b2\u2010blockers add\u2010on to monotherapy significantly reduced systolic and diastolic blood pressure as compared with non\u2010\u03b2\u2010blocker monotherapy (weighted mean difference in mm Hg [95% confidence interval]: \u22124.1 [\u22126.0, \u22122.2] and \u22123.7 [\u22124.6, \u22122.8], respectively). These results were consistent across the comparisons with diuretics (systolic pressure, \u221210.2 [\u221214.2, \u22126.2]; diastolic pressure, \u22125.4 [\u22128.2, \u22122.6]), CCBs (systolic pressure, \u22124.1 [\u22127.1, \u22121.0]; diastolic pressure, \u22122.8 [\u22124.1, \u22121.5]), and ACEIs\/ARBs (systolic pressure, \u22122.9 [\u22124.3, \u22121.5]; diastolic pressure, \u22124.2 [\u22125.0, \u22123.4]). There was no significant difference in blood pressure lowering effects between combinations with and without a \u03b2\u2010blocker (systolic pressure, \u22121.3\u00a0mm Hg [\u22125.8, 3.2]; diastolic pressure, \u2212.3\u00a0mm Hg [\u22122.7, 2.1]). Metoprolol add\u2010on or combination therapy had a significantly greater blood pressure reduction than non\u2010\u03b2\u2010blocker therapy (systolic pressure, \u22123.6\u00a0mm Hg [\u22125.9, \u22121.3]; diastolic pressure, \u22122.1\u00a0mm Hg [\u22123.5, \u2212.7]). In conclusion, non\u2010atenolol \u03b2\u2010blockers are effective in lowering blood pressure as add\u2010on to monotherapy or as a component of combination antihypertensive therapy. In line with the current hypertension guideline recommendations, \u03b2\u2010blockers can and should be used in combination with other antihypertensive drugs.<\/jats:p>","DOI":"10.1111\/jch.14616","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T07:49:41Z","timestamp":1675928981000},"page":"227-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood pressure lowering effects of \u03b2\u2010blockers as add\u2010on or combination therapy: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"25","author":[{"given":"Qian\u2010Hui","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine State Key Laboratory of Medical Geonomics Shanghai Key Laboratory of Hypertension Center for Epidemiological Studies and Clinical Trials The Shanghai Institute of Hypertension National Research Center for Translational Medicine at Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chongqing Institute of Hypertension Department of Hypertension and Endocrinology Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Qing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Xiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardiovascular Department The First Affiliated Hospital Fujian Medical University Fujian Institute of Hypertension  Fuzhou 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