{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:55:24Z","timestamp":1776455724320,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL113004"],"award-info":[{"award-number":["NIH R01 HL113004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HL007457\u201037"],"award-info":[{"award-number":["5T32HL007457\u201037"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resistant hypertension (RHTN), defined as blood pressure (BP) that is uncontrolled with \u22653 medications, including a long\u2010acting thiazide diuretic, also includes a subset with BP that is controlled with \u22654 medications, so\u2010called controlled RHTN. This resistance is attributed to intravascular volume excess. Patients with RHTN overall have a higher prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction compared to patients with non\u2010RHTN. We tested the hypothesis that patients with controlled RHTN due to the intravascular volume excess have higher left ventricular mass index (LVMI), higher prevalence of LVH, larger intracardiac volumes, and more diastolic dysfunction compared to patients with controlled non\u2010resistant hypertension (CHTN), defined as BP controlled with \u22643 anti\u2010hypertensive medications. Patients with controlled RHTN (n\u00a0=\u00a069) or CHTN (n\u00a0=\u00a063) who were treated at the University of Alabama at Birmingham were offered enrollment and underwent cardiac magnetic resonance imaging. Diastolic function was assessed by peak filling rate, time needed in diastole to recover 80% of stroke volume, E:A ratios and left atrial volume. LVMI was higher in patients with controlled RHTN (64.4\u00a0\u00b1\u00a022.5 vs 56.9\u00a0\u00b1\u00a011.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017). Intracardiac volumes were similar in both groups. Diastolic function parameters were not significantly different between groups. There were no significant differences in age, gender, race, body mass index, dyslipidemia between the two groups. The findings show that patients with controlled RHTN have higher LVMI, but comparable diastolic function to those of patients with CHTN.<\/jats:p>","DOI":"10.1111\/jch.14625","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T06:46:27Z","timestamp":1680590787000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-6656","authenticated-orcid":false,"given":"Faris","family":"Matanes","sequence":"first","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Jordan University of Science and Technology  Irbid Jordan"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-6537","authenticated-orcid":false,"given":"Mohammed","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Division of nephrology University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Velasco","sequence":"additional","affiliation":[{"name":"Cardiology Department Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Sharifov","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Kreps","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Dudenbostel","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric K","family":"Judd","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Division of nephrology University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven G","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"VA Medical Center  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Vascular Biology and Hypertension Program University of Alabama at Birmingham  Birmingham USA"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"e53","article-title":"Resistant hypertension: detection, evaluation, and management: a scientific statement From the","volume":"72","author":"Carey RM","year":"2018","journal-title":"Am Heart Assoc Hypertens"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.170308"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03565"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03850"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068064"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.142"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.11.1159"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90617-V"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01165-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.03.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.04.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.080150"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138529"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.084"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.02.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037059409102246"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000087"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-5-18"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200402000-00009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05782"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001076"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328363e964"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00341-X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.528"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10965"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-30"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.879304"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.06.040"},{"issue":"5","key":"e_1_2_9_32_1","first-page":"303","article-title":"A formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"Du Bois D","year":"1989","journal-title":"Nutrition"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.141531"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001264"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.3.800"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.905"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138680.89536.A9"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960281008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.83"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109213.10461.F6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2011.00501.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl526"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.15"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11818"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.3.844"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9811"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14304"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:00:41Z","timestamp":1697860841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/jch.14625"],"URL":"https:\/\/doi.org\/10.1111\/jch.14625","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}