{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T08:11:35Z","timestamp":1785658295761,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared the efficacy and safety of third\u2010standard\u2010dose triple and third\u2010standard\u2010dose dual antihypertensive combination therapies in patients with mild to moderate hypertension. This was a phase II multicenter, randomized, double\u2010blind, parallel\u2010group trial. After a 4\u2010week placebo run\u2010in period, 245 participants were randomized to the third\u2010dose triple combination (ALC group; amlodipine 1.67\u00a0mg + losartan potassium 16.67\u00a0mg + chlorthalidone 4.17\u00a0mg) or third\u2010dose dual combination (AL group; amlodipine 1.67\u00a0mg + losartan potassium 16.67\u00a0mg, LC group; losartan potassium 16.67\u00a0mg + chlorthalidone 4.17\u00a0mg, AC group; amlodipine 1.67\u00a0mg + chlorthalidone 4.17\u00a0mg) therapy groups and followed up for 8\u00a0weeks. The mean systolic blood pressure (BP) reduction was \u201018.3\u00a0\u00b1\u00a013.2, \u201013.0\u00a0\u00b1\u00a013.3, \u201016.3\u00a0\u00b1\u00a012.4, and \u201013.8\u00a0\u00b1\u00a013.2\u00a0mmHg in the ALC, AL, LC, and AC groups, respectively. The ALC group showed significant systolic BP reduction compared to the AL and AC groups at weeks 4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.010 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018, respectively) and 8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.017 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.036, respectively). At week 4, the proportion of systolic BP responders was significantly higher in the ALC group (42.6%) than in the AL (22.0%), LC (23.3%), and AC (27.1%) groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.021, and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045, respectively). At week 8, the proportion of systolic and diastolic BP responders was significantly higher in the ALC group (59.7%) than in the AL (39.3%) and AC (42.4%) groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.022 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049, respectively) at week 8. Third\u2010standard\u2010dose triple antihypertensive combination therapy demonstrated early effective BP control compared to third\u2010standard\u2010dose dual combination therapies, without increasing adverse drug reactions in patients with mild\u2010to\u2010moderate hypertension.<\/jats:p>","DOI":"10.1111\/jch.14656","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T05:20:33Z","timestamp":1682400033000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of efficacy and safety between third\u2010dose triple and third\u2010dose dual antihypertensive combination therapies in patients with hypertension"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-2145","authenticated-orcid":false,"given":"Ki\u2010Chul","family":"Sung","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cardiovascular Center Korea University Anam Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-3627","authenticated-orcid":false,"given":"Moo\u2010Yong","family":"Rhee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Dongguk University Ilsan Hospital  Goyang\u2010si Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-8562","authenticated-orcid":false,"given":"Myung\u2010Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chonnam National University Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asan Medical\u00a0Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Wook","family":"Lim","sequence":"additional","affiliation":[{"name":"Cardiology Division Cardiac center CHA Bundang medical center CHA University  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungil","family":"Park","sequence":"additional","affiliation":[{"name":"Dong\u2010A University Hospital Dong\u2010A University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center  Daegu Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok\u2010Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine and Cardiovascular Center Yongin Severance Hospital  Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-658X","authenticated-orcid":false,"given":"Sungha","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology Severance Hospital Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-6504","authenticated-orcid":false,"given":"Jinho","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Hanyang University College of Medicine  Seoul Republic of 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