{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:57:13Z","timestamp":1784606233104,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High blood pressure (BP) and type\u20102 diabetes (T2DM) are forerunners of chronic kidney disease and left ventricular dysfunction. Home BP telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling risk stratification and personalized prevention. UPRIGHT\u2010HTM (NCT04299529) is an investigator\u2010initiated, multicenter, open\u2010label, randomized trial with blinded endpoint evaluation designed to assess the efficacy of HTM plus UPP (experimental group) over HTM alone (control group) in guiding treatment in asymptomatic patients, aged 55\u201375 years, with \u22655 cardiovascular risk factors. From screening onwards, HTM data can be freely accessed by all patients and their caregivers; UPP results are communicated early during follow\u2010up to patients and caregivers in the intervention group, but at trial closure in the control group. From May 2021 until January 2023, 235 patients were screened, of whom 53 were still progressing through the run\u2010in period and 144 were randomized. Both groups had similar characteristics, including average age (62.0 years) and the proportions of African Blacks (81.9%), White Europeans (16.7%), women 56.2%, home (31.2%), and office (50.0%) hypertension, T2DM (36.4%), micro\u2010albuminuria (29.4%), and ECG (9.7%) and echocardiographic (11.5%) left ventricular hypertrophy. Home and office BP were 128.8\/79.2\u00a0mm\u00a0Hg and 137.1\/82.7\u00a0mm\u00a0Hg, respectively, resulting in a prevalence of white\u2010coat, masked and sustained hypertension of 40.3%, 11.1%, and 25.7%. HTM persisted after randomization (48 681 readings up to 15 January 2023). In conclusion, results predominantly from low\u2010resource sub\u2010Saharan centers proved the feasibility of this multi\u2010ethnic trial. The COVID\u201019 pandemic caused delays and differential recruitment rates across centers.<\/jats:p>","DOI":"10.1111\/jch.14664","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T08:16:06Z","timestamp":1683360966000},"page":"521-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial\u2014First progress report"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-6600","authenticated-orcid":false,"given":"Babangida S.","family":"Chori","sequence":"first","affiliation":[{"name":"Center for Environmental Sciences Hasselt University  Diepenbeek Belgium"},{"name":"Non\u2010Profit Research Association Alliance for the Promotion of Preventive Medicine  Mechelen 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A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Clinical Sciences College of Health Sciences University of Abuja  Gwagwalada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ojonojima","family":"Ajanya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Clinical Sciences College of Health Sciences University of Abuja  Gwagwalada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga O.","family":"Abiodun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Federal Medical Center Jabi  Jabi Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Anya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Federal Medical Center Jabi  Jabi Abuja 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