{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:46:19Z","timestamp":1785577579164,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This retrospective study compared cardiovascular (CV) outcomes between initial \u03b2\u2010blocker (BB)\u00a0+\u00a0calcium channel blocker (CCB) dual therapy (\u201cB\u00a0+\u00a0C\u201d) and other initial dual therapies in Chinese newly diagnosed hypertensive patients. In this study, all patients in a regional electronic database with newly diagnosed hypertension from January 01, 2012 to December 31, 2016 who received any initial optimal dual therapy recommended by the Chinese hypertension guideline were included. 1:2 propensity score matching (PSM) was used to balance baseline characteristics between patients receiving B\u00a0+\u00a0C and patients receiving other initial dual therapies (\u201cOthers\u201d). The primary outcome was major adverse cardiovascular events (MACE) that occurred from January 01, 2012 to December 31, 2017, consisting of non\u2010fatal stroke, non\u2010fatal myocardial infarction (MI), non\u2010fatal chronic heart failure (CHF), and all\u2010cause death. Cox proportional hazard models were used to compare these CV outcomes in the 2 matched cohorts. After the PSM, 6227 patients receiving B\u00a0+\u00a0C and 12\u00a0454 patients receiving Others were included. Compared to patients receiving Others, patients receiving B\u00a0+\u00a0C had a significantly lower risk of MACE (hazard ratio [HR] 0.85; 95% confidential interval [CI] 0.78\u20130.92; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), non\u2010fatal stroke (HR 0.89; 95% CI 0.81\u20130.98; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) and non\u2010fatal CHF (HR 0.74; 95% CI 0.63\u20130.86; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). Additionally, differences in risks of non\u2010fatal MI and all\u2010cause death between the 2 treatment cohorts were not statistically significant. In conclusion, BB\u00a0+\u00a0CCB initial dual therapy was associated with a lower risk of MACE, stroke, and CHF than other optimal initial dual therapies recommended by the Chinese hypertension guideline in Chinese newly diagnosed hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.14665","type":"journal-article","created":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T04:38:30Z","timestamp":1682829510000},"page":"440-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular outcomes of \u03b2\u2010blocker\u2014calcium channel blocker initial dual therapy vs. other initial dual therapies in Chinese patients with hypertension: A real\u2010world retrospective study"],"prefix":"10.1111","volume":"25","author":[{"given":"Junxiong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian 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