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Adults aged 18\u201374\u00a0years from the Northwest China Natural Population Cohort: Ningxia Project (CNC\u2010NX) were recruited in this study. Association between body fat composition and HHcy was evaluated by logistic regression model. Restricted cubic spline was used to find nonlinear association. The impact of the interaction between HHcy and body fat composition on CVD was evaluated using the addition interaction model and mediation effect model. In total, 16\u00a0419 participants were included in this research. Body fat percentage, visceral fat level, and abdominal fat thickness were positively associated with overall HHcy (<jats:italic>p<\/jats:italic>for trend\u00a0&lt;\u00a0.001). Adjusted odds ratios (ORs) in quarter 4 were 1.181 (95% CI: 1.062, 1.313), 1.202 (95% CI: 1.085, 1.332), and 1.168 (95% CI: 1.055, 1.293) for body fat percentage, visceral fat level, and abdominal fat thickness, respectively, compared with those in quarter 1. Subgroup analysis indicated age, estimated glomerular filtration rate (eGFR), total cholesterol (TC), low density lipoprotein cholesterol (LDL\u2010C), and CVD were the interaction factors of body fat percentage, visceral fat level, abdominal fat thickness with HHcy (all<jats:italic>p<\/jats:italic>for interaction\u00a0&lt;\u00a0.05). ORs of CVD were higher in participants with HHcy and high body fat. Body fat composition was positively associated with HHcy, indicating that reducing body, abdominal, and visceral fat content may lower the risk of HHcy and CVD.<\/jats:p>","DOI":"10.1111\/jch.14666","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T08:24:06Z","timestamp":1683361446000},"page":"573-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between body fat composition and hyperhomocysteinemia in the analysis of the baseline data of the Northwest China Natural Population Cohort: Ningxia Project (CNC\u2010NX)"],"prefix":"10.1111","volume":"25","author":[{"given":"Wanlu","family":"Liu","sequence":"first","affiliation":[{"name":"School of Public Health and Management Ningxia Medical University, Xingqing District Yinchuan 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