{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:24:17Z","timestamp":1780367057772,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900308"],"award-info":[{"award-number":["81900308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current hypertension guideline emphasizes combination therapy, especially single\u2010pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutively identified 964 treatment na\u00efve hypertensive patients in a large academic hospital from 01\/31\/2019 to 01\/31\/2020. All patients were grouped into (1) young aged, age\u00a0&lt;\u00a055; (2) middle\u2010aged, 55\u2264age\u00a0&lt;\u00a065; and (3) older aged, age \u226565. The multivariable regression model examined the factors associated with the combination therapy by age group. Overall, 80 (8.3%) were young, 191 (19.8%) were middle, and 693 (71.9%) were older aged. Compared with older age, younger patients were more likely to be male, highly educated, regularly exercised, have metabolic syndrome, and less likely to have cardiovascular\u2010related comorbidities, with a lower systolic but higher diastolic pressure. Only one in five patients used SPC, and the prevalence decreased with age. Besides hypertension grade, young patients without catheterization or echo test were less likely to receive multiple therapies, while older patients who were male with lower weight and lower risk levels were less likely to receive multiple therapies. In conclusion, combination therapy, especially SPC, was underused in the targeted hypertensive population. Our contemporary population study showed that young patients (&lt;55) without a history of catheterization or echo examination and male older\u2010aged (\u226565) patients with low\u2010risk classification were the population most likely to be neglected. Such information can help triage medical care resources in improving SPC use.<\/jats:p>","DOI":"10.1111\/jch.14668","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:49:05Z","timestamp":1684345745000},"page":"545-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age\u2010specific differences in hypertension combination management and associated factors influencing treatment choice"],"prefix":"10.1111","volume":"25","author":[{"given":"Jianfei","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Renji Hospital School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Practice Renji Hospital School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-1214","authenticated-orcid":false,"given":"Chuanxi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Yangpu Hospital Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengye","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital School of Medicine, Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Yangpu Hospital Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30955-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31145-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"10","article-title":"Report on cardiovascular health and diseases in China 2021: an updated summary","volume":"26","author":"Writing committee of the report on cardiovascular health and diseases in China","year":"2021","journal-title":"Chin J Cardiovasc Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_2_8_8_1","unstructured":"OrganizationWH.Guideline for the pharmacological treatment of hypertension in adults.2021; 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