{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:30:48Z","timestamp":1790890248711,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although hypertension is considered high intravascular pressure, impairing circadian blood pressure (BP) has been shown to potentially contribute to poor clinical outcomes. Systemic immune\u2010inflammation index (SII), based on platelet, neutrophil, and lymphocyte counts, has been established as a strong prognostic marker in cardiovascular disease. The role of inflammation in the pathogenesis of hypertension is a well\u2010known issue and inflammatory markers are associated with BP variability. We aimed to investigate whether there is a relationship between circadian BP changes and SII in newly diagnosed hypertensive patients. The study population consisted of 196 newly diagnosed hypertensive patients without LVH. In total, 76 (38%) patients had a dipper BP pattern, 60 (31%) patients had a non\u2010dipper BP pattern, and 60 (31%) patients had a reverse\u2010dipper BP pattern. SII was calculated according to Multivariate logistic regression analysis revealed SII and HDL\u2010C as an independent predictors of reverse\u2010dipper circadian pattern in newly diagnosed hypertensive patients. The cut\u2010off value of the SII for reverse\u2010dipper hypertension in a ROC curve analysis was\u00a0&gt;639.73\u00a0with 63.3% sensitivity and 84.2% specificity. Our study showed that the SII level was higher in the reverse\u2010dipper hypertension patient group than in the dipper and non\u2010dipper hypertension groups. Furthermore, SII was an independent predictor of newly diagnosed reverse\u2010dipper hypertensive patients. The high SII value in newly diagnosed hypertensive patients can be used as an early warning parameter to identify reverse\u2010dipper hypertension patients.<\/jats:p>","DOI":"10.1111\/jch.14688","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:16:14Z","timestamp":1689743774000},"page":"700-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The relationship between the systemic immune\u2010inflammation index and reverse\u2010dipper circadian pattern in newly diagnosed hypertensive patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-120X","authenticated-orcid":false,"given":"Muammer","family":"Karakayali","sequence":"first","affiliation":[{"name":"Department of Cardiology Kafkas University School of Medicine Kars 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