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The aims of this systematic review, and network meta\u2010analysis are to rank the risk of cough induced by different ACEIs and between ACEI and placebo, ARB or calcium channel blockers (CCB). We performed a systematic review, and network meta\u2010analysis of randomized controlled trials to rank the risk of cough induced by each ACEI and between ACEI and placebo, ARB or CCB. A total of 135 RCTs with 45,420 patients treated with eleven ACEIs were included in the analyses. The pooled estimated relative risk (RR) between ACEI and placebo was 2.21 (95% CI: 2.05\u20132.39). ACEI had more incidences of cough than ARB (RR 3.2; 95% CI: 2.91, 3.51), and pooled estimated of RR between ACEI and CCB was 5.30 (95% CI: 4.32\u20136.50) Moexipril ranked as number one for inducing cough (SUCRA 80.4%) and spirapril ranked the least (SUCRA 12.3%). The order for the rest of the ACEIs are as follows: ramipril (SUCRA 76.4%), fosinopril (SUCRA 72.5%), lisinopril (SUCRA 64.7%), benazepril (SUCRA 58.6%), quinapril (SUCRA 56.5%), perindopril (SUCRA 54.1%), enalapril (SUCRA 49.7%), trandolapril (SUCRA 44.6%) and, captopril (SUCRA 13.7%). All ACEI has the similar risk of developing a cough. ACEI should be avoided in patients who have risk of developing cough, and an ARB or CCB is an alternative based on the patient's comorbidity.<\/jats:p>","DOI":"10.1111\/jch.14695","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T09:06:41Z","timestamp":1688720801000},"page":"661-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Angiotensin\u2010converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Yiyun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Clinical Medical College, Fujian Medical University Fuzhou China"},{"name":"Department of Cardiology The First Affiliated Hospital of Xiamen University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Affairs Management Department Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice Y.","family":"Kung","sequence":"additional","affiliation":[{"name":"University of Alberta, John W. 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