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The China stroke primary prevention trial showed that combining 0.8\u00a0mg folic acid (FA) with angiotensin\u2010converting enzyme inhibitor (ACEI) can effectively lower plasma total homocysteine (tHcy) and blood pressure (BP); and reduce first stroke risk by additional 21% compared to ACEI alone. However, intolerance to ACEI is common in Asians and amlodipine can be alternative. This is a multicenter, randomized, double\u2010blind, parallel\u2010controlled clinical trial (RCT) which evaluated whether amlodipine combined with FA is more efficacious than amlodipine alone in lowering tHcy and BP among Chinese hypertensive with hyperhomocysteinemia and intolerance to ACEI. 351 Eligible patients were randomly assigned by 1:1:1 ratio to receive amlodipine\u2010FA tablet daily (amlodipine 5\u00a0mg\/FA 0.4\u00a0mg, A group); amlodipine 5\u00a0mg\/FA 0.8\u00a0mg tablet daily (B group); amlodipine 5\u00a0mg daily (C group, control group). Follow\u2010up was conducted at 2, 4, 6, and 8\u00a0weeks. The primary outcome was efficacy of lowering both tHcy and BP at the end of 8\u2010week treatment. Compared with C group, A group had a significantly higher rate of lowering both tHcy and BP (23.3%\u00a0vs. 6.0%; Odds Ratio [OR], 8.68; 95% CI, 3.04\u201024.78,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); B group also had a higher rate of lowering both tHcy and BP (20.3%\u00a0vs. 6.0%; OR: 5.90; 95% CI, 2.11\u201016.47,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). This RCT showed amlodipine combined with FA compared with amlodipine alone, each had significantly higher efficacy of lowering both tHcy and BP. No difference was found in BP\u2010lowering and occurrence of adverse events between the three groups.\n                  <\/jats:p>","DOI":"10.1111\/jch.14697","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T16:32:37Z","timestamp":1689093157000},"page":"689-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, double\u2010blind, parallel\u2010controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Huihui","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University Nanchang 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