{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:14:55Z","timestamp":1752282895940,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There lacks real\u2010world study with a large sample size assessing olmesartan medoxomil\u2010amlodipine besylate (OM\u2010AML) tablet. Therefore, this study aimed to evaluate the efficacy and safety of OM\u2010AML tablet in patients with essential hypertension. Totally, 1341 patients from 36 medical centers with essential hypertension who took OM\u2010AML (20\/5\u00a0mg) tablet were analyzed in the current prospective, single\u2010arm, multi\u2010center, real\u2010world study (SVK study). Seated systolic blood pressure (SeSBP) and seated diastolic blood pressure (SeDBP) at baseline, week (W)4 and W8 were measured. The mean (\u00b1SE) change of SeSBP\/SeDBP was \u201010.8\u00a0\u00b1\u00a00.4\/\u20106.6\u00a0\u00b1\u00a00.3\u00a0mmHg at W4 and \u201012.7\u00a0\u00b1\u00a00.5\/\u20107.6\u00a0\u00b1\u00a00.3\u00a0mmHg at W8, respectively. At W4, 78.8% and 29.0% patients achieved BP target by China and American Heart Association (AHA) criteria; at W8, 84.7% and 36.5% patients reached blood pressure (BP) target by China and AHA criteria, accordingly. Meanwhile, 80.2% and 86.4% patients achieved BP response at W4 and W8, respectively. Home\u2010measured SeSBP and SeDBP decreased from W1 to W8 (both<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Besides, patients\u2019 and physicians\u2019 satisfaction were elevated at W8 compared with W0 (both<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The medication possession rate was 94.8% from baseline to W4 and 91.3% from baseline to W8. The most common drug\u2010related adverse events were nervous system disorders (4.6%), vascular disorders (2.6%), and general disorders and administration site conditions (2.3%) by system organ class, which were generally mild and manageable. In conclusion, OM\u2010AML tablet is one of the best antihypertensive agents in patients with essential hypertension.<\/jats:p>","DOI":"10.1111\/jch.14700","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:49:14Z","timestamp":1693892954000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of olmesartan medoxomil\u2010amlodipine besylate tablet in Chinese patients with essential hypertension: A prospective, single\u2010arm, multi\u2010center, real\u2010world study"],"prefix":"10.1111","volume":"26","author":[{"given":"Zhaoqiang","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Tongren Hospital 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