{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:52Z","timestamp":1790837092560,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The next\u2010generation mineralocorticoid receptor blocker (MRB) esaxerenone has favorable antihypertensive effects in patients who do not respond to treatment with first\u2010line antihypertensive agents and may be beneficial as a second\u2010line treatment. However, MRBs are currently considered a fourth\u2010line treatment as there is no clinical evidence comparing the efficacy of esaxerenone with other classes of antihypertensive agents. The multicenter, randomized, open\u2010label, parallel\u2010group EXCITE\u2010HT study will evaluate the efficacy and safety of esaxerenone as a second\u2010line agent in the treatment of Japanese patients with uncontrolled essential hypertension. After a 4\u2010week run\u2010in period, patients will receive either esaxerenone or trichlormethiazide for 12\u00a0weeks per the package insert and the Japanese Society of Hypertension Guidelines for the Management of Hypertension. At Weeks 4 and 8, the dose of esaxerenone or trichlormethiazide may be increased. Blood pressure (home [morning and bedtime] and office), serum biomarkers, and urinary biomarkers will be measured. The primary efficacy endpoint is the change from baseline in morning home systolic blood pressure\/diastolic blood pressure to the end of treatment. The EXCITE\u2010HT study is expected to validate the non\u2010inferiority of esaxerenone to trichlormethiazide and provide the first evidence for the early use of esaxerenone as a second\u2010line agent in the treatment of Japanese patients with uncontrolled essential hypertension instead of its current use as a fourth\u2010line agent.<\/jats:p>","DOI":"10.1111\/jch.14705","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T05:29:48Z","timestamp":1691472588000},"page":"861-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rationale and design of a multicenter randomized study comparing the efficacy and safety of esaxerenone versus trichlormethiazide in patients with uncontrolled essential hypertension: EXCITE\u2010HT study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Hypertension Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Katsuya Clinic Hyogo Japan"},{"name":"Department of Clinical Gene Therapy Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Primary Medical Science Department Daiichi Sankyo Co., Ltd Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Data Intelligence Department Daiichi Sankyo Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Primary Medical Science Department Daiichi Sankyo Co., Ltd Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Shimosawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory School of Medicine International University of Health and Welfare Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13751"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-023-01174-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04262"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.037"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07201"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11388"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2022.2137490"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371\u2010021\u201000533\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-0377-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01056-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13569"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0314-7"},{"key":"e_1_2_10_15_1","first-page":"755","article-title":"The efficacy and safety of esaxerenone for patients with grade III hypertension. 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