{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:46:07Z","timestamp":1783579567215,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy including chlorthalidone 25\u00a0mg with telmisartan 80\u00a0mg plus amlodipine 5\u00a0mg in hypertensive patients. This is a multicenter, double\u2010blind, active\u2010controlled, phase 3, randomized trial. Patients are randomized to triple combination (telmisartan 40\u00a0mg\/amlodipine 5\u00a0mg\/chlorthalidone 12.5\u00a0mg, TEL\/AML\/CHTD group) or dual combination (telmisartan 40\u00a0mg\/amlodipine 5\u00a0mg, TEL\/AML group) treatment and then dose up titration to TEL 80\/AML5\/CHTD25mg and TEL80\/AML5, respectively. The primary endpoint is the change of mean sitting systolic blood pressure (MSSBP) at week 8. A Target BP achievement rate, a response rate, and the safety endpoints are also evaluated. Total 374 patients (mean age\u00a0=\u00a060.9\u00a0\u00b1\u00a010.7\u00a0years, male\u00a0=\u00a078.3%) were randomized to the study. The baseline MSSBPs\/diastolic BPs were 149.9\u00a0\u00b1\u00a012.2\/88.5\u00a0\u00b1\u00a010.4\u00a0mm Hg. After 8\u00a0weeks treatment, the change of MSSBPs at week 8 are \u221219.1\u00a0\u00b1\u00a014.9\u00a0mm Hg (TEL\/AML\/CHTD) and \u221211.4\u00a0\u00b1\u00a014.7\u00a0mm Hg (TEL\/AML) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). The achievement rates of target BP (53.8% vs. 37.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0017) and responder rate (54.8% vs. 35.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0001) at week 8 were significantly higher in TEL\/AML\/CHTD. There are no serious adverse event and no one discontinued medication due to adverse event. Among the TEL 80\/AML5\/CHTD25mg treatment group, patients of female or age\u00a0\u2265\u00a065\u00a0years old showed higher rate of target BP achievement than relatively young male. (61.4 vs. 46.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042) Our study showed standard dose triple combination of telmisartan 80\u00a0mg\/amlodipine 5\u00a0mg\/chlorthalidone 25\u00a0mg is efficacious and safe in treatment of primary hypertension. Target BP achievement with triple therapy would be facilitated in female or old age.<\/jats:p>","DOI":"10.1111\/jch.14707","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T05:35:58Z","timestamp":1692855358000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of standard dose triple combination of telmisartan 80\u00a0mg\/amlodipine 5\u00a0mg\/chlorthalidone 25\u00a0mg in primary hypertension: A randomized, double\u2010blind, active\u2010controlled, multicenter phase 3 trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Eun Joo","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Yeouido St. Mary's Hospital Catholic University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Dong\u2010A University Hospital Dong\u2010A University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Asan Medical Center University of Ulsan  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyuk","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Seoul St. Mary's Hospital Catholic University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Chol","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Gil Hospital Gachon University College of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-6504","authenticated-orcid":false,"given":"Jinho","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Hanyang University Hospital Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine  Ansan South 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