{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:24:01Z","timestamp":1747185841768,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors performed this study to investigate the efficacy and safety of a rosuvastatin (RSV)\/amlodipine (AML) polypill compared with those of atorvastatin (ATV)\/AML polypill. We included 259 patients from 21 institutions in Korea. Patients were randomly assigned to 1 of 3 treatment groups: RSV 10\u00a0mg\/AML 5\u00a0mg, RSV 20\u00a0mg\/AML 5\u00a0mg, or ATV 20\u00a0mg \/AML 5\u00a0mg. The primary endpoint was the efficacy of the RSV 10.20\u00a0mg\/AML 5\u00a0mg via percentage changes in LDL\u2010C after 8\u00a0weeks of treatment, compared with the ATV 20\u00a0mg \/AML 5\u00a0mg. There was a significant difference in the mean percentage change of LDL\u2010C at 8\u00a0weeks between the RSV 10\u00a0mg\/AML 5\u00a0mg and the ATV 20\u00a0mg\/AML 5\u00a0mg (full analysis set [FAS]: \u22127.08%, 95% CI: \u221211.79 to \u22122.38,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0034, per\u2010protocol analysis set [PPS]: \u22126.97%, 95% CI: \u221211.76 to \u22122.19,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0046). Also, there was a significant difference in the mean percentage change of LDL\u2010C at 8\u00a0weeks between the RSV 20\u00a0mg\/AML 5\u00a0mg and the ATV 20\u00a0mg\/AML 5\u00a0mg (FAS: \u221210.13%, 95% CI: \u221215.41 to \u22124.84,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0002, PPS: \u221210.96%, 95% CI: \u221215.98 to \u22125.93,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). There was no significant difference in the adverse events rates between RSV 10\u00a0mg\/AML 5\u00a0mg, RSV 20\u00a0mg\/AML 5\u00a0mg, and ATV 20\u00a0mg\/AML 5\u00a0mg. In conclusion, while maintaining safety, RSV 10\u00a0mg\/AML 5\u00a0mg and the RSV 20\u00a0mg\/AML 5\u00a0mg more effectively reduced LDL\u2010C compared with the ATV 20\u00a0mg \/AML 5\u00a0mg (Clinical trial: NCT03951207).<\/jats:p>","DOI":"10.1111\/jch.14715","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:34:46Z","timestamp":1692423286000},"page":"828-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Randomized, multicenter, parallel, open, phase 4 study to compare the efficacy and safety of rosuvastatin\/amlodipine polypill versus atorvastatin\/amlodipine polypill in hypertension patient with dyslipidemia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-928X","authenticated-orcid":false,"given":"Hae Won","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0028-9647","authenticated-orcid":false,"given":"Seung\u2010Pyo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Joon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-3276","authenticated-orcid":false,"given":"Jae Kean","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Daegu Catholic University Medical Center Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung\u2010Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoo\u2010Rok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kangdong 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