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ELABELA is the second endogenous ligand of the apelin receptor (APJ) and is associated with the pathogenesis of preeclampsia. In a previous study, the authors found that the downregulation of ELABELA expression is closely related to late\u2010onset preeclampsia, which may be a marker for the clinical diagnosis of late\u2010onset preeclampsia. In this study, the authors again collected 120 maternal blood samples, including 60 pregnant women with a medical diagnosis of late\u2010onset preeclampsia. ELISA results showed that the serum ELABELA concentration in late\u2010onset preeclampsia pregnant women (12.57\u00a0\u00b1\u00a07.77\u00a0ng\/mL) was significantly lower than that in normal pregnant women (36.99\u00a0\u00b1\u00a023.58\u00a0ng\/mL), which was consistent with previously reported results. Therefore, the authors used an ELABELA monoclonal antibody to label four colloidal gold nanoparticles with different diameters (15, 30, 55, and 150\u00a0nm) and developed a transverse\u2010flow immunochromatographic band for the rapid and accurate detection of serum ELABELA levels. The strip test shows that colloidal gold with a diameter of 30\u00a0nm can be used as a good ELABELA detection marker and had more than 90% positive detection effect. Therefore, the authors hope that the colloidal gold strip with ELABELA as the diagnostic index developed by us will be popularized and applied in clinical diagnosis.<\/jats:p>","DOI":"10.1111\/jch.14724","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:52:11Z","timestamp":1695631931000},"page":"932-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting late\u2010onset preeclampsia by detecting ELABELA content using an immunochromatographic colloidal gold test strip"],"prefix":"10.1111","volume":"25","author":[{"given":"Na","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Sciences Nanjing Normal University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Nanjing Normal University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Pan'an Mason Medical Technology Co., LTD.  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