{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:19:36Z","timestamp":1790061576664,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent in patients with polymyositis and dermatomyositis (PM\/DM). Owning elevated levels of reactive oxygen species, patients with PM\/DM have lower concentrations of UA in comparison with healthy people. We explored a potential association between UA levels and hypertension in PM\/DM and evaluated whether this association is independent of hypertension risk factors, PM\/DM characteristics and relevant drugs. A total of 472 PM\/DM patients were assessed. UA and related laboratory data were measured. Demographic, hypertension\u2010related factors, PM\/DM characteristics and drug use were assessed as potential covariates. Results were analyzed using logistic models to test the independence of the association between UA and hypertension. UA levels were higher in hypertension subjects compared to non\u2010hypertensive PM\/DM patients [284.70 (239.93\u2010357.38) vs 264.00(222.50\u2010322.75), <jats:italic>p<\/jats:italic>\u00a0=\u00a0.017]. When adjusted for hypertension risk factors, PM\/DM characteristics and drugs, the odds of being a hypertensive PM\/DM patient per 1\u00a0\u03bcmol\/L UA increase were significantly increased: odds ratio\u00a0=\u00a01.473 (95% confidence interval:1.063\u20102.042, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.020). This cross\u2010sectional study suggests that UA levels are independently associated with hypertension in PM\/DM patients.<\/jats:p>","DOI":"10.1111\/jch.14730","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:50:31Z","timestamp":1697079031000},"page":"1019-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0448-5206","authenticated-orcid":false,"given":"mei","family":"liu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of\u00a0Medicine Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kening","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4086","authenticated-orcid":false,"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0162-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr159"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114259"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00273.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f240bf"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.056"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22520"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2010.01470.x"},{"key":"e_1_2_10_10_1","first-page":"686","article-title":"Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review","volume":"35","author":"Zhang L","year":"2012","journal-title":"Clinical cardiology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23302"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-207172"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2016.1220380"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_10_16_1","article-title":"ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European society of hypertension endorsed by the European renal association (ERA) and the international society of hypertension (ISH)","author":"Co\u2010Chair RK","year":"2023","journal-title":"J Hyperten"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/329862"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9792412"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-4-12"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_18_19"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1051\/bmdcn\/2018080316"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-009-0038-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01174"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-373"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)44307-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20344"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00283.2001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00074.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345509"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93017-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050572"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2016"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2012.00701.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.8.924"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-6-817"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917070-00001"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000069700.62727.C5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0477-1"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086216"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402111666150529130922"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4527"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6858"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90143-I"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1396"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.493270"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21103"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1782"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206623"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01177.2006"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2019-0024"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:18:18Z","timestamp":1699445898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/jch.14730"],"URL":"https:\/\/doi.org\/10.1111\/jch.14730","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]},"assertion":[{"value":"2023-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}