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However, milder forms of autonomous aldosterone secretion have been demonstrated to exist below the diagnostic thresholds of current PHA guidelines, and associate with clinically relevant cardiovascular risk. PHAencompasses a spectrum of renin independent aldosterone production, progressing from a subclinical state in normotensives to a full\u2010blown clinical syndrome representing the resistant hypertension population. The authors propose the Syndrome of Inappropriately Elevated Aldosterone Secretion (SIALDS) concept as a potential new paradigm for understanding and diagnosing PHA and expanded diagnostic approach to improve early detection even in well\u2010controlled hypertension. The authors also delve into the impact of treatments, including mineralocorticoid receptor antagonists and emerging aldosterone synthase inhibitors. Furthermore, The authors outline future research directions, proposing clinical trials to investigate the long\u2010term identification and treatment outcomes of SIALDS.<\/jats:p>","DOI":"10.1111\/jch.14740","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T07:55:28Z","timestamp":1698220528000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Redefining primary hyperaldosteronism as \u201cThe Syndrome of Inappropriate Aldosterone Secretion (SIALDS)\u201d: A common but unrecognized cause of hypertension"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6215-3956","authenticated-orcid":false,"given":"Rajat","family":"Lamba","sequence":"first","affiliation":[{"name":"Department for Continuing Education Kellogg College University of Oxford  Oxfordshire 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