{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:03Z","timestamp":1787015403196,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consecutive readings and the estimated glomerular filtration rate was derived from serum creatinine (eGFRcrt) and cystatin C (eGFRcys). Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 \u03bcg\/dL). The statistical methods included multivariable\u2010adjusted mixed models and interval\u2010censored Cox regression analysis. The 234 workers analyzed were on average 28.5 years old and included 91.9% men. The baseline BL concentration was 4.35 \u03bcg\/dL and increased 3.17\u2010fold over follow\u2010up (median: 2.03 years; range: 0.92\u20136.45 years). The changes in BP and RF were not significantly correlated with the follow\u2010up\u2010to\u2010baseline BL ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2265 .51 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2265 .18, respectively). The fully\u2010adjusted changes in systolic\/diastolic BP associated with a doubling of BL were \u22120.25\/\u22120.12\u00a0mm Hg (CI: \u22120.94 to 0.44\/\u22120.66 to 0.42\u00a0mm Hg). Accordingly, the incidence of stage\u20101 or \u20102 hypertension was not associated with the BL change (\n                    <jats:italic>p<\/jats:italic>\n                    \u2265 .063). Similarly, the changes in eGFRcrt and eGFRcys associated with a 3\u2010fold BL increment were not significant, amounting to \u22120.70\u00a0mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    (CI: \u22121.70 to 0.30\u00a0mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    ) and \u22121.06\u00a0mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    (\u22122.16 to 0.03\u00a0mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    ). In conclusion, the BP and RF responses to an over 3\u2010fold BL increment were small and not significant confirming the safety of modern lead\u2010handing facilities operating under current safety rules.\n                  <\/jats:p>","DOI":"10.1111\/jch.14748","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:33:18Z","timestamp":1699435998000},"page":"1086-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Blood pressure and renal function responses in workers exposed to lead for up to six years"],"prefix":"10.1111","volume":"25","author":[{"given":"Yu\u2010Ling","family":"Yu","sequence":"first","affiliation":[{"name":"Research Unit Environment and Health KU Leuven Department of Public Health and Primary Care University of Leuven  Leuven Belgium"},{"name":"Non\u2010Profit Research Association Alliance for the Promotion of Preventive Medicine  Mechelen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Wei","family":"An","sequence":"additional","affiliation":[{"name":"Research Unit Environment and Health KU Leuven Department of Public Health and Primary Care University of Leuven  Leuven Belgium"},{"name":"Non\u2010Profit Research Association Alliance for the Promotion of Preventive Medicine  Mechelen Belgium"},{"name":"Department of Cardiovascular Medicine Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics National Research Centre for Translational Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai General Hospital, Shanghai Jiaotong University School of Medicine Shanghai 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Hasselt University  Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-1637","authenticated-orcid":false,"given":"Jan A.","family":"Staessen","sequence":"additional","affiliation":[{"name":"Non\u2010Profit Research Association Alliance for the Promotion of Preventive Medicine  Mechelen Belgium"},{"name":"Biomedical Science Group Faculty of Medicine University of Leuven  Leuven 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