{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:14:05Z","timestamp":1778940845603,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20212ACB206019 20224BAB206090"],"award-info":[{"award-number":["20212ACB206019 20224BAB206090"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased plasma homocysteine (Hcy) has been identified as one of the important risk factors for cardiovascular disease. However, the association between plasma Hcy and peripheral artery disease (PAD) is still controversial. This study aimed to investigate the association between plasma Hcy and PAD and the potential modifier factors in Chinese hypertensive adults. A total of 25\u00a0300 hypertensive patients aged 18\u00a0years or older were included in the analysis in this cross\u2010sectional study. The outcome was PAD, which defined as an ankle\u2010brachial index \u22640.90 in either limb. Multiple logistic regression was used to analyze the relationship between plasma Hcy and PAD. The median plasma Hcy was 14.00 (interquartile range: 11.60\u201317.80)\u00a0\u03bcmol\/L. There was a significant positive association between plasma Hcy and PAD (per SD increment; OR: 1.13; 95% CI: 1.06\u20131.19). Patients in the upper plasma Hcy tertile (\u226516.16\u00a0\u03bcmol\/L) were associated with a 53% increased risk of PAD compared with patients in the lower tertile (&lt;12.33\u00a0\u03bcmol\/L) after adjustment for multiple potential confounders. Subgroup analyses showed the association between Hcy and PAD was robust among various strata. Among Chinese adults with hypertension, plasma Hcy is an independent risk factor for PAD. This finding may improve the risk stratification of PAD.<\/jats:p>","DOI":"10.1111\/jch.14766","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:54:01Z","timestamp":1708430041000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross\u2010sectional study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0151-3489","authenticated-orcid":false,"given":"Chuanli","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-6105","authenticated-orcid":false,"given":"Yumeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-119X","authenticated-orcid":false,"given":"Peixu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u00b4e","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-6318","authenticated-orcid":false,"given":"Xiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-1988","authenticated-orcid":false,"given":"Xiaoshu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Sub\u2010center of National Clinical Research Center for Cardiovascular Diseases  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center  Nanchang Jiangxi China"},{"name":"Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30255-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.010601"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.2.197"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866889"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1745"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2015.75"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70152-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02077.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.02.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.10.1077"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.13.1506"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10100959"},{"issue":"12","key":"e_1_2_10_18_1","first-page":"976","article-title":"Prevention of stroke relies on valid control \u201cH\u201d type hypertension","volume":"47","author":"Hu DY","year":"2008","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.05.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S267122"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01258-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.719369"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab022"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvab282"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22475"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.05.007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.04.010"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00870-1"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2481"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.608679"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2005"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11596"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2007.0584"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.08.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.2.335"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6670"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00617-X"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.808675"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-021-0871-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7010074"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2244"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.041"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102181"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj090"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.179"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:11:40Z","timestamp":1709809900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jch.14766"],"URL":"https:\/\/doi.org\/10.1111\/jch.14766","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}