{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:26:55Z","timestamp":1787243215632,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Microalbuminuria and hyperuricemia management are crucial for the integrated management of hypertensive patients. This retrospective post hoc analysis aims to evaluate the optimal allisartan\u2010isoproxil\u2010based combination regimen for hypertensive patients with microalbuminuria or hyperuricemia. A total of 460 hypertensive patients with microalbuminuria and 486 hypertensive patients with hyperuricemia were included in this study. All patients were initially treated with allisartan\u2010isoproxil for 4\u00a0weeks. Thereafter, patients with blood pressure (BP)\u00a0&lt;\u00a0140\/90\u00a0mmHg continued the monotherapy for 8\u00a0weeks; patients with BP \u2265140\/90\u00a0mmHg were randomly assigned in a 1:1 ratio to receive allisartan\u2010isoproxil + amlodipine (Group A + C) or allisartan\u2010isoproxil + indapamide (Group A + D) for 8\u00a0weeks. The changes of BP, urinary albumin and serum uric acid (UA) were measured. In patients with microalbuminuria, the urinary albumin\/creatinine ratio (UACR) significantly decreased by 10.4\u00a0mg\/g in Group A + C (vs. baseline\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0035) and 24.2\u00a0mg\/g in Group A + D (vs baseline\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001), intergroup\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0NS. In patients with hyperuricemia, serum UA level decreased by 44.5\u00a0\u00b5mol\/L in Group A + C (vs. baseline\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0003), but increased by 27.2\u00a0\u00b5mol\/L in Group A + D (vs. baseline\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0167), intergroup\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001. The results suggest that for hypertensive patients with microalbuminuria, angiotensin receptor blocker (ARB) + calcium channel blocker (CCB) or ARB+ diuretic both are good choices based on their improvement of microalbuminuria and BP. But for patients with hyperuricemia, ARB + diuretic may further increase the level of UA.\n                  <\/jats:p>","DOI":"10.1111\/jch.14773","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:21:11Z","timestamp":1707276071000},"page":"241-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of allisartan\u2010isoproxil\u2010based combination antihypertensive regimen in hypertensive patients with microalbuminuria or hyperuricemia"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-2813","authenticated-orcid":false,"given":"Ningling","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Hypertension Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of 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