{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:14:49Z","timestamp":1785294889182,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2020D01C224"],"award-info":[{"award-number":["2020D01C224"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with systemic autoimmune diseases, such as systemic lupus erythematosus, were at a higher risk for preeclampsia. The causal relationship between immunological inflammation and preeclampsia (PE) remains uncertain. We aimed to investigate the causal relationship between circulating immune inflammation and PE. Genetically predicted blood immune cells and circulating inflammatory proteins were identified using two genome\u2010wide association studies (GWAS). We used a two\u2010sample Mendelian randomization (MR) method\u00a0to determine whether circulating immunological inflammation causes PE. Our findings indicated that ten immunophenotypes were identified to be significantly associated with PE risk: CD62L\u2010 Dendritic Cell Absolute Count, CD86+ myeloid Dendritic Cell %Dendritic Cell, CD62L\u2010 myeloid Dendritic Cell Absolute Count, CD86+ myeloid Dendritic Cell Absolute Count, CD62L\u2010 myeloid Dendritic Cell %Dendritic Cell, CD62L\u2010 CD86+ myeloid Dendritic Cell %Dendritic Cell, CD62L\u2010 CD86+ myeloid Dendritic Cell Absolute Count, CD16 on CD14+ CD16+ monocyte, HLA DR+ Natural Killer Absolute Count, and T cell Absolute Count. Ninety\u2010one inflammation\u2010related proteins had no statistically significant effect on PE following false discovery rate (FDR) correction. Certain proteins exhibited unadjusted low <jats:italic>p<\/jats:italic>\u2010values that merited mention. These proteins include interleukin\u201010 (OR\u00a0=\u00a00.76, 95%CI\u00a0=\u00a00.63\u20130.93, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006), fibroblast growth factor 21 (OR\u00a0=\u00a01.23, 95%CI\u00a0=\u00a01.01\u20131.47, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035), and Caspase 8 (OR\u00a0=\u00a00.65, 95%CI\u00a0=\u00a00.50\u20130.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). The ELISA analysis demonstrated elevated levels of FGF\u201021 and decreased levels of IL\u201010 and Caspase\u20108 in the plasma of patients with PE. These findings reveal that immunophenotypes\u00a0and circulating inflammatory proteins may induce PE, confirming the importance of peripheral Immunity\u2010Inflammation in PE. The discovery has the potential to lead to earlier detection and more effective treatment techniques.<\/jats:p>","DOI":"10.1111\/jch.14775","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T06:59:51Z","timestamp":1710313191000},"page":"474-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The causal role of circulating immunity\u2010inflammation in preeclampsia: A Mendelian randomization"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiaolei","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Obstetrics The Fifth Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding College of Biological Sciences China Agricultural University  Beijing 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