{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:03:46Z","timestamp":1788444226515,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to compare and evaluate the efficacy of the blood pressure (BP) control and cholesterol\u2010lowering effects and safety of combination therapy with telmisartan, rosuvastatin, and ezetimibe versus rosuvastatin and ezetimibe double therapy or telmisartan single therapy in dyslipidemia patients with hypertension. After a wash\u2010out\/therapeutic lifestyle change period of \u22654\u00a0weeks, a total of 100 eligible patients were randomized and received one of three treatments for 8\u00a0weeks: (1) telmisartan 80\u00a0mg\/rosuvastatin 20\u00a0mg\/ezetimibe 10\u00a0mg (TRE), (2) rosuvastatin 20\u00a0mg\/ezetimibe 10\u00a0mg (RE), or (3) telmisartan 80\u00a0mg (T). The primary endpoint was the efficacy evaluation of TRE by comparing changes in mean sitting systolic blood pressure (msSBP) and mean percentage change in low\u2010density lipoprotein\u2010C (LDL\u2010C) from baseline after 8\u00a0weeks of treatment.<\/jats:p><jats:p>The least square (LS) mean (SE) changes in msSBP at 8\u00a0weeks compared with baseline were \u221223.02 (3.04) versus \u22127.18 (3.09) mmHg in the TRE and RE groups, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), and \u221225.80 (2.74) versus \u221214.92 (2.65) mmHg in the TRE and T groups, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0005). The percentage changes in the mean (SD) LDL\u2010C at 8\u00a0weeks compared with baseline were \u221254.97% (3.49%) versus \u22120.17% (3.23%) in the TRE and T groups, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). No serious adverse events occurred, and no statistically significant differences in the incidence of overall AEs and adverse drug reactions occurred among the three groups.<\/jats:p><jats:p>TRE therapy significantly decreased msSBP and LDL\u2010C compared to RE or T therapy with comparable safety and tolerability profiles.<\/jats:p>","DOI":"10.1111\/jch.14778","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:14:12Z","timestamp":1707293652000},"page":"262-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of combination therapy with telmisartan, rosuvastatin, and ezetimibe in patients with dyslipidemia and hypertension: A randomized, double\u2010blind, multicenter, therapeutic confirmatory, phase III clinical trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-409X","authenticated-orcid":false,"given":"Chan 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