{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:02:45Z","timestamp":1783958565859,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to elucidate the clinical diagnostic value of plasma catecholamines and their metabolites for pheochromocytoma and paraganglioma (PPGL)\u2010induced secondary hypertension using ultraperformance liquid chromatography\u2010mass spectrometry (UPLC\u2010MS\/MS). The study population included 155 patients with PPGL that were divided into the PPGL with hypertension (<jats:italic>n<\/jats:italic>\u00a0=\u00a079) and a PPGL without hypertension (<jats:italic>n<\/jats:italic>\u00a0=\u00a076) groups, and 90 healthy volunteers and 90 patients with primary hypertension as the control groups. UPLC\u2010MS\/MS was performed to detect plasma levels of catecholamines and their metabolites, including dopamine, vanillylmandelic acid (VMA), norepinephrine, metanephrine, and normetanephrine. Receiver operating characteristic curves were generated to analyze the diagnostic value of the plasma levels of catecholamines and their metabolites in PPGL\u2010induced secondary hypertension. Patients in the primary hypertension and PPGL without hypertension groups had higher levels of dopamine, VMA, norepinephrine, metanephrine, and normetanephrine than patients in the normal group (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). On the other hand, patients in the PPGL with hypertension group had higher levels of dopamine, VMA, norepinephrine, metanephrine, and normetanephrine than patients in the normal, primary hypertension, and PPGL without hypertension groups (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Collectively, our findings showed that dopamine, VMA, norepinephrine, metanephrine, and normetanephrine are all effective biomarkers for the diagnosis of PPGL and PPGL\u2010induced secondary hypertension.<\/jats:p>","DOI":"10.1111\/jch.14779","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T07:28:31Z","timestamp":1709969311000},"page":"416-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical diagnosis of pheochromocytoma and paraganglioma\u2010induced secondary hypertension through UPLC\u2010MS\/MS analysis of plasma catecholamines and their metabolites"],"prefix":"10.1111","volume":"26","author":[{"given":"Weiyun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine General Hospital of Southern Theater Command of PLA  Guangzhou China"},{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou 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