{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:42:24Z","timestamp":1757540544169,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the levels of High\u2010Mobility Group Box 1 (HMGB1), Receptor for Advanced Glycation Endproducts (RAGE), T Helper 17 cells (Th17), Regulatory T cells (Treg), and related cytokines in the peripheral blood of patients with severe preeclampsia (SPE) complicated with acute heart failure (AHF) to explore the expression changes in these indicators. In total, 96 patients with SPE admitted to Gansu Provincial Maternity and Child\u2010care Hospital between June 2020 and June 2022 were included in the study. The patients were divided into SPE+AHF (40 patients) and SPE (56 patients) groups based on whether they suffered from AHF. Additionally, 56 healthy pregnant women who either received prenatal examinations or were admitted to our hospital for delivery during the same period were selected as the healthy control group. An enzyme\u2010linked immunosorbent assay was performed to detect the expression levels of HMGB1, RAGE, interleukin (IL)\u201017, IL\u20106, transforming growth factor \u03b2 (TGF\u2010\u03b2), IL\u201010, and NT\u2010proBNP in plasma. Flow cytometry was employed to determine the percentages of Th17 and Treg cells. Compared to the healthy control group, the SPE+AHF and SPE groups had higher plasma levels of HMGB1 and RAGE expression, higher Th17 percentage and Th17\/Treg ratio, and lower Treg percentage. Compared to the SPE group, the SPE+AHF group had higher plasma levels of HMGB1 and RAGE expression, higher Th17 percentage and Th17\/Treg ratio, and lower Treg percentage (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.05). In patients with SPE with AHF, plasma HMGB1 was positively correlated with RAGE, Th17, Th17\/Treg, IL\u201017, and IL\u20106 and was negatively correlated with TGF\u2010\u03b2 and IL\u201010 (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.05). Our findings revealed that patients with SPE with AHF had elevated levels of HMGB1 and RAGE while exhibiting Th17\/Treg immune imbalance, suggesting that the abnormal expression of these indicators may be involved in the pathogenesis of SPE with AHF.<\/jats:p>","DOI":"10.1111\/jch.14784","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T06:58:05Z","timestamp":1711349885000},"page":"431-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of changes in high\u2010mobility group box 1, receptor for advanced glycation endproducts, and T helper 17\/regulatory T balance in severe preeclampsia with acute heart failure"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0358-3648","authenticated-orcid":false,"given":"Chen","family":"De","sequence":"first","affiliation":[{"name":"First Clinical Medical School Lanzhou University  Lanzhou China"},{"name":"Emergency Medical Center Gansu Provincial Maternity and Child\u2010care Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Allergy Gansu Provincial Maternity and Child\u2010care Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"jingjing","sequence":"additional","affiliation":[{"name":"Medical Genetics Center Gansu Provincial Maternity and Child\u2010care Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Honghong","sequence":"additional","affiliation":[{"name":"Emergency Medical Center Gansu Provincial Maternity and Child\u2010care Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuo","family":"Kun","sequence":"additional","affiliation":[{"name":"Emergency Medical Center Gansu Provincial Maternity 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