{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:50Z","timestamp":1788544190302,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K09477"],"award-info":[{"award-number":["16K09477"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17610"],"award-info":[{"award-number":["19K17610"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single\u2010nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle\u2010related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used \u22654 antihypertensive drugs. Patients with controlled hypertension had BP controlled using \u22643 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014; least significant at rs11105378: 5.7% vs. 0.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035; most nonsignificant at rs12817819: 5.1% vs. 10%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 and OR: 7.62, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high\u2010risk patients who are more likely to require more antihypertensive medications.<\/jats:p>","DOI":"10.1111\/jch.14785","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T16:14:51Z","timestamp":1709396091000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-3720","authenticated-orcid":false,"given":"Yusuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Center for Novel and Exploratory Clinical Trials (Y\u2010NEXT) Yokohama City University  Yokohama Japan"},{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University 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