{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:15:13Z","timestamp":1781291713572,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates the expression and significance of urinary protein and coagulation\u2010fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally, 110 patients with gestational hypertension (gestational hypertension group) were included for comparative analysis. General information, laboratory indicators, urinary protein, and coagulation\u2010fibrinolysis indicator levels were collected for each group. Significant differences were observed in blood pressure among groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while uric acid, serum creatinine, aspartate transaminase, alanine transaminase, and triglycerides showed no significant differences (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Total cholesterol, triglycerides, and low\u2010density Lipoprotein levels in severe preeclampsia were higher than those in mild preeclampsia and gestational hypertension groups, whereas high\u2010density lipoprotein, albumin, and platelet levels were lower in severe preeclampsia. No significant differences were observed in prothrombin time or D\u2010dimer levels among groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse maternal and infant outcomes in severe preeclampsia patients. The study concludes that urinary protein and coagulation\u2010fibrinolysis indicators are elevated in preeclampsia, particularly in severe preeclampsia cases, suggesting their potential use as diagnostic influencing factors for severe preeclampsia.<\/jats:p>","DOI":"10.1111\/jch.14789","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T16:14:14Z","timestamp":1709396054000},"page":"374-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary protein and coagulation\u2010fibrinolysis indicators in preeclampsia: Expression and significance"],"prefix":"10.1111","volume":"26","author":[{"given":"Zhen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3988-5293","authenticated-orcid":false,"given":"Xiaoqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Renmin Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1356"},{"key":"e_1_2_11_3_1","first-page":"101123","volume-title":"Prevention of Preeclampsia","author":"Ma'ayeh M","year":"2020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2019.1638396"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221126172"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.15766\/mep_2374-8265.10832"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"2463","article-title":"Potential urine biomarkers for gestational hypertension and preeclampsia","volume":"19","author":"Guo HX","year":"2019","journal-title":"Mol Med Rep"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"67","article-title":"ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists","volume":"77","author":"Practice ACoO","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"issue":"5","key":"e_1_2_11_9_1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 task force on hypertension in pregnancy","volume":"122","author":"ACoOa G, TFoHi P","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"e1","article-title":"ACOG practice bulletin no. 202: gestational hypertension and preeclampsia","volume":"133","author":"Obstetricians ACo, Gynecologists","year":"2019","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_11_1","first-page":"161","article-title":"Guidelines for the diagnosis and treatment of hypertensive disorders complicating pregnancy (2015)","volume":"19","author":"Obstetrics PHGo, Association GBoCM","year":"2016","journal-title":"Chin J Obst Gynecol"},{"key":"e_1_2_11_12_1","first-page":"227","article-title":"Guidelines for the diagnosis and treatment of hypertensive disorders in pregnancy","volume":"55","author":"Yang Z","year":"2020","journal-title":"Chin J Obst Gynecol"},{"issue":"5","key":"e_1_2_11_13_1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 task force on hypertension in pregnancy","volume":"122","author":"Pregnancy T","year":"2013","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2018.10.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.01.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2019-0037"},{"issue":"13","key":"e_1_2_11_17_1","first-page":"7222","article-title":"A new predicting model of preeclampsia based on peripheral blood test value","volume":"24","author":"Han Q","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.11.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.14503\/THIJ-20-7459"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.18996"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.04.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0480-z"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802011000200004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00751-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7815214"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.04.014"},{"issue":"3","key":"e_1_2_11_27_1","article-title":"Urinary protein\u2010to\u2010creatinine ratio: an indicator of adverse clinical outcomes in preeclampsia with proteinuria","volume":"14","author":"Chadha A","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2019.1590720"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026482"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.973271"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN110447"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004149"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2021.102972"},{"issue":"9","key":"e_1_2_11_34_1","first-page":"6805","article-title":"Multivariate logistic regression analysis of preeclampsia in patients with pregnancy induced hypertension and the risk predictive value of monitoring platelet, coagulation function and thyroid hormone in pregnant women","volume":"14","author":"Zeng L","year":"2022","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1586854"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05334.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14467"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2017.03.005"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2013.12.006"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.54530\/jcmc.72"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.04.035"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:03:38Z","timestamp":1712833418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jch.14789"],"URL":"https:\/\/doi.org\/10.1111\/jch.14789","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,2]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}