{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:37:54Z","timestamp":1756636674577,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL169954","R01 LM006910","T15 LM007079"],"award-info":[{"award-number":["R01 HL169954","R01 LM006910","T15 LM007079"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous work comparing safety and effectiveness outcomes for new initiators of angiotensin converting\u2010enzyme inhibitors (ACEi) and thiazides demonstrated more favorable outcomes for thiazides, although cohort definitions allowed for addition of a second antihypertensive medication after a week of monotherapy. Here, we modify the monotherapy definition, imposing exit from cohorts upon addition of another antihypertensive medication. We determine hazard ratios (HR) for 55 safety and effectiveness outcomes over six databases and compare results to earlier findings. We find, for all primary outcomes, statistically significant differences in effectiveness between ACEi and thiazides were not replicated (HRs: 1.11, 1.06, 1.12 for acute myocardial infarction, hospitalization with heart failure and stroke, respectively). While statistical significance is similarly lost for several safety outcomes, the safety profile of thiazides remains more favorable. Our results indicate a less striking difference in effectiveness of thiazides compared to ACEi and reflect some sensitivity to the monotherapy cohort definition modification.<\/jats:p>","DOI":"10.1111\/jch.14793","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:44:00Z","timestamp":1710852240000},"page":"425-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative safety and effectiveness of angiotensin converting enzyme inhibitors and thiazides and thiazide\u2010like diuretics under strict monotherapy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-867X","authenticated-orcid":false,"given":"Tara V.","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics Columbia University Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health University of California  Los Angeles California USA"},{"name":"Department of Biostatistics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn J.","family":"Schuemie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health University of California  Los Angeles California USA"},{"name":"Global Epidemiology Johnson &amp; Johnson  Titusville New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Suchard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health University of California  Los Angeles California USA"},{"name":"Department of Human Genetics David Geffen School of Medicine at UCLA University of California  Los Angeles California USA"},{"name":"VA Informatics and Computing Infrastructure US Department of Veterans Affairs  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Hripcsak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Columbia University Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1726481"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32317-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0099-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv254"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy120"},{"key":"e_1_2_10_7_1","first-page":"574","article-title":"Observational health data sciences and informatics (OHDSI): opportunities for observational researchers","volume":"216","author":"Hripcsak G","year":"2015","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/70.1.41"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CER.S40357"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02596-4"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:03:50Z","timestamp":1712833430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jch.14793"],"URL":"https:\/\/doi.org\/10.1111\/jch.14793","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"type":"print","value":"1524-6175"},{"type":"electronic","value":"1751-7176"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"assertion":[{"value":"2023-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}