{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:52:06Z","timestamp":1777179126100,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is conflicting evidence in select mouse models and humans that suggest angiotensin\u2010converting enzyme 2 expression is increased due to treatment with angiotensin converting enzyme inhibitors and angiotensin receptor blockers (ACEI\/ARBs). Given the wide range of conditions that these medications treat, further evaluation is necessary to determine safety in the context of COVID\u201019. We sought to determine the association between use of ACEI\/ARBs and COVID\u201019 severity in patients with essential hypertension. We included 714 patients with essential hypertension diagnosed with COVID\u201019 and admitted to University of Iowa Healthcare from March 1, 2020 to June 29, 2021. Severity of COVID\u201019 infection was assessed based on mortality, length of stay in hospital, intensive care unit admission, and use of supplemental oxygen, invasive ventilation, and vasopressors. Multivariable logistic and linear regression analyses were used for binary and continuous outcomes, respectively. Prior exposure to ACEI\/ARBs before admission was significantly associated with lower mortality (OR: 0.454, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015), shorter length of stay in hospital (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and decreased adjusted odds of intensive care admission (OR: 0.719; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.042). The present results suggest that patients with essential hypertension hospitalized with COVID\u201019 who had a prescription for ACEI\/ARBs prior to admission exhibited less severe COVID\u201019 and lower in\u2010hospital mortality.<\/jats:p>","DOI":"10.1111\/jch.14869","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T14:19:58Z","timestamp":1720966798000},"page":"1039-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between renin\u2010angiotensin antagonism and COVID\u201019\u2013related mortality in patients with essential hypertension: A single center, retrospective cohort study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-7286","authenticated-orcid":false,"given":"Vijayvardhan","family":"Kamalumpundi","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Roy J. and Lucille A. Carver College of Medicine Iowa City Iowa USA"},{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-642X","authenticated-orcid":false,"given":"Linhai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Roy J. and Lucille A. Carver College of Medicine Iowa City Iowa USA"},{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3847-428X","authenticated-orcid":false,"given":"Erin E.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-8813","authenticated-orcid":false,"given":"Elham","family":"Shams","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ologibe","family":"Ofori","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"},{"name":"University of Iowa College of Liberal Arts and Sciences Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8769-7311","authenticated-orcid":false,"given":"Assim","family":"Eddin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-6234","authenticated-orcid":false,"given":"Marcelo L. G.","family":"Correia","sequence":"additional","affiliation":[{"name":"Roy J. and Lucille A. Carver College of Medicine Iowa City Iowa USA"},{"name":"Division of Endocrinology and Metabolism University of Iowa Healthcare Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.WHO COVID\u201019 Dashboard.World Health Organization. Accessed 2024.https:\/\/data.who.int\/dashboards\/covid19\/cases"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118142"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.510461"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31131-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01704-y"},{"issue":"21","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.030240","article-title":"Association between hypertension and diabetes control and COVID\u201019 severity: national patient\u2010centered clinical research network, United States","volume":"12","author":"Jackson SL","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3594"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026143"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023535"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1077959"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31030-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270763"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092903"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:18:40Z","timestamp":1729264720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,14]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jch.14869"],"URL":"https:\/\/doi.org\/10.1111\/jch.14869","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,14]]},"assertion":[{"value":"2024-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}