{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:41:57Z","timestamp":1776890517085,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the clinical characteristics of primary aldosteronism (PA) screened from patients with hypertension in China. The participants were hypertensive patients who were suspected of PA and registered in the China Primary Aldosteronism Prospective Study. Plasma aldosterone\u2010to\u2010renin ratio (ARR) was used as the screening test. In patients screened positive for PA, that is, an ARR exceeding the thresholds and plasma aldosterone concentration (PAC)\u00a0&gt;\u00a0100 pg\/mL, a confirmatory test was performed for diagnosis. Patients with PA underwent a CT scan and adrenal venous sampling for subtyping. Of the 1497 screened patients, 754 (50.4%) had an ARR exceeding the diagnostic threshold and 637 (84.5% of those eligible) were registered. These registered hypertensive patients with suspected PA had a mean (standard deviation) age of 52.6\u00a0\u00b1\u00a012.1 years, and included 442 (58.6%) women. In multiple stepwise logistic regression, the significant odds ratios for the presence of diagnosed (<jats:italic>n<\/jats:italic>\u00a0=\u00a0490) versus suspected and non\u2010diagnosed PA (<jats:italic>n<\/jats:italic>\u00a0=\u00a0147) were 4.54 (95% CI: 2.78\u20107.39) for a history of hypokalemia, 0.79 (95% CI: 0.64\u20100.98) for a 0.9\u00a0mmol\/l higher serum total cholesterol, and 2.25 (95% CI: 1.63\u20103.10) for a doubling of PAC in the supine or standing\/sitting position. In multiple stepwise logistic regression, the significant odds ratios for the presence of unilateral (<jats:italic>n<\/jats:italic>\u00a0=\u00a0135) versus bilateral PA (<jats:italic>n<\/jats:italic>\u00a0=\u00a053) were 3.04 (95% CI: 1.90\u20104.87) for a 0.4\u00a0mmol\/l lower minimum serum potassium concentration and 1.86 (95% CI: 1.20\u20102.86) for a 0.3\u00a0mmol\/l higher serum high\u2010density lipoprotein cholesterol. PA might be a biochemical continuum in the adrenal hypersecretion of aldosterone as well as hypokalemia.<\/jats:p>","DOI":"10.1111\/jch.14874","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:24:15Z","timestamp":1721651055000},"page":"1082-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics of primary aldosteronism screened from Chinese patients with hypertension: The China primary aldosteronism prospective study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-2240","authenticated-orcid":false,"given":"Zhe","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7970-6991","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-3504","authenticated-orcid":false,"given":"Yi\u2010Bang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Centre for Epidemiological Studies and Clinical Trials The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine People's Hospital of Ningxia Hui Autonomous Region  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanxi Bethune Hospital  Taiyuan Shanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-8803","authenticated-orcid":false,"given":"Gai\u2010Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Centre for Epidemiological Studies and Clinical Trials The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai 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