{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:22:15Z","timestamp":1772886135862,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardio\u2010ankle vascular index (CAVI) is an innovative indicator of large\u2010artery stiffness, which is evaluated by the pulse wave velocity (PWV) measurement. Mortality and morbidity due to cardiovascular diseases among the general public with high\u2010risk conditions such as hypertension are usually associated with arterial stiffness. CAVI modelizes the hazard of future cardiovascular events with standard risk factors. Additionally, the \u201cEuropean Society of Hypertension and Cardiology\u201d included the aortic PWV assessment in managing hypertension in their updated guidelines in 2007. We conducted this systematic review to collect, summarize, and evaluate the evidence from relevant reported studies. A literature search of four databases was conducted comprehensively until February 2024. Cardiovascular events are the primary outcome of interest in this study, cardiovascular events that have been defined as major adverse cardiac events include \u201cheart failure\u201d, \u201cstroke\u201d, \u201cmyocardial infarction\u201d, \u201ccardiovascular deaths\u201d, \u201cstable angina pectoris\u201d, \u201ccoronary revascularization\u201d, and \u201cunstable angina pectoris\u201d. We included five studies with a 11\u00a0698 sample size in this systematic review. All five prospective studies investigated composite cardiovascular events as an outcome. Three of them revealed a statistically significant prediction ability of CAVI to assess Cardiovascular disease (CVD) risk. Further analysis is required. Current evidence is insufficient to confirm the predictive power of CAVI in the assessment of cardiovascular risk in hypertensive patients. CAVI is modestly associated with incidents of CVD risk. It is necessary to conduct further studies to assess CAVI concerning CVD predictor measures in the masses and nations other than Asia.<\/jats:p>","DOI":"10.1111\/jch.14878","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T05:38:36Z","timestamp":1724391516000},"page":"1005-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive significance of cardio ankle vascular index for the assessment of cardiovascular risk in hypertensive patients: A systematic review"],"prefix":"10.1111","volume":"26","author":[{"given":"Chiranjeevee R.","family":"Saravanan","sequence":"first","affiliation":[{"name":"Internal Medicine Madras Medical College  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhayu R.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Cardiology Lincoln County Hospital  Lincoln UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pugazhendi","family":"Inban","sequence":"additional","affiliation":[{"name":"Internal Medicine St. Mary's General Hospital and Saint Clare's Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Harini","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Internal Medicine Vijaya Hospitals  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himani H.","family":"Pattani","sequence":"additional","affiliation":[{"name":"Internal Medicine Gujarat University  Ahmedabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krupanagram","family":"Santoshi","sequence":"additional","affiliation":[{"name":"Internal Medicine MNR Medical College  Sangareddy India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyma","family":"Bamba","sequence":"additional","affiliation":[{"name":"Internal Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurmehar","family":"Singh","sequence":"additional","affiliation":[{"name":"Internal Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadarshi","family":"Prajjwal","sequence":"additional","affiliation":[{"name":"Internal Medicine Bharati Vidyapeeth Medical College Pune  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raunak","family":"Ranjan","sequence":"additional","affiliation":[{"name":"SCGMC Nanded  Nanded India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4534","authenticated-orcid":false,"given":"Mohammed Dheyaa Marsool","family":"Marsool","sequence":"additional","affiliation":[{"name":"Internal Medicine Al\u2010Kindy College of Medicine University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-263X","authenticated-orcid":false,"given":"Omniat","family":"Amir","sequence":"additional","affiliation":[{"name":"Internal Medicine Al\u2010Manhal Academy  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2021.07.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(02)11911\u20108"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3167518"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2021.1883052"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artres.2011.03.005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201015\u20101356"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.31385"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14294"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_13_1","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions | Cochrane Training [Internet]. 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