{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:22:03Z","timestamp":1747185723452,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070432","82070435","82270469","82370426"],"award-info":[{"award-number":["82070432","82070435","82270469","82370426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated fasting hypertriglyceridemia as predictors of all\u2010cause, cardiovascular, and non\u2010cardiovascular mortality in an elderly male Chinese population, while accounting for various conventional cardiovascular risk factors. Our participants were elderly men recruited from residents living in a suburban town of Shanghai (\u226560 years of age, <jats:italic>n<\/jats:italic>\u00a0=\u00a01583). Hypertriglyceridemia was defined as a fasting serum triglycerides concentration \u22651.70\u00a0mmol\/L. Subgroup analyses were performed according to current smoking (yes vs. no), alcohol intake (yes vs. no), and the presence and absence of hypertension and hyperglycemia. During a median of 7.9 years follow\u2010up, all\u2010cause, cardiovascular, and non\u2010cardiovascular deaths occurred in 279, 112, and 167 participants, respectively. After adjustment for confounding factors, fasting hypertriglyceridemia was not significantly (<jats:italic>p<\/jats:italic> \u2265\u00a0.33) associated with the risk of all\u2010cause, cardiovascular, and non\u2010cardiovascular mortality. However, there was significant (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.03) interaction between hypertriglyceridemia and the presence and absence of hypertension in relation to all\u2010cause mortality. In normotensive, but not hypertensive individuals, hypertriglyceridemia was significantly associated with a higher risk of all\u2010cause mortality (hazard ratio 1.57, 95% confidence interval 1.06\u20132.31). In further non\u2010parametric analyses in normotensive individuals, the age\u2010standardized rate for all\u2010cause mortality increased from 18.9 in quartile 1 to 20.0, to 24.7, and to 39.9 per 1000 person\u2010years in quartiles 2, 3, and 4 of serum triglycerides concentration, respectively (<jats:italic>p<\/jats:italic><jats:sub>trend\u00a0<\/jats:sub>=\u00a0.0004). Similar results were observed for cardiovascular mortality. Our study in elderly male Chinese showed that fasting hypertriglyceridemia was associated with a higher risk of all\u2010cause and cardiovascular mortality in patients with normotension but not those with hypertension.<\/jats:p>","DOI":"10.1111\/jch.14887","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T05:50:12Z","timestamp":1724133012000},"page":"1163-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fasting hypertriglyceridemia in relation to mortality in an elderly male Chinese population"],"prefix":"10.1111","volume":"26","author":[{"given":"Xin\u2010Yu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yuan\u2010Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Centre for Epidemiological Studies and Clinical Trials The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-0663","authenticated-orcid":false,"given":"Chang\u2010Sheng","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Centre for Epidemiological Studies and Clinical Trials The Shanghai Institute of 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