{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T05:01:41Z","timestamp":1786770101327,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes. Nevertheless, the association between aldosterone and obesity still needs to be clarified. In this review, the authors discuss the role of white adipose tissue in linking obesity, aldosterone excess, and hypertension. The consequences of aldosterone excess in obesity are presented as genomic, non\u2010genomic, and non\u2010epithelial effects. Moreover, the authors emphasize the value of interference with aldosterone pathophysiology (as with mineralocorticoid antagonists) in obesity, thus reducing the adverse clinical impact of aldosterone in myocardial infarction, heart failure, kidney dysfunction, and associated mortality.<\/jats:p>","DOI":"10.1111\/jch.14898","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T11:40:40Z","timestamp":1732534840000},"page":"1384-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances?"],"prefix":"10.1111","volume":"26","author":[{"given":"Houry","family":"Puzantian","sequence":"first","affiliation":[{"name":"Hariri School of Nursing American University of Beirut  Beirut Lebanon"},{"name":"Department of Pharmacology and Toxicology Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Renal Electrolyte and Hypertension Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Texas Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0065"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00447"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.01.001"},{"key":"e_1_2_5_5_1","first-page":"1496","article-title":"Health effects of overweight and obesity in 195 countries","volume":"377","author":"Afshin A","year":"2017","journal-title":"N Engl J Med"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008733"},{"key":"e_1_2_5_7_1","unstructured":"WHO.Obesity and overweight.2022. Accessed November 11 2024.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight"},{"key":"e_1_2_5_8_1","unstructured":"CDC.Adult obesity facts.2024. Accessed November 11 2024.https:\/\/www.cdc.gov\/obesity\/adult-obesity-facts\/?CDC_AAref_Val=https:\/\/www.cdc.gov\/obesity\/data\/adult.html"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00465-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207751"},{"key":"e_1_2_5_12_1","unstructured":"CDC. A Report Card.Diabetes in The United States.2024. Accessed November 11 2024.https:\/\/www.cdc.gov\/diabetes\/communication-resources\/diabetes-statistics.html?CDC_AAref_Val=https:\/\/www.cdc.gov\/diabetes\/library\/socialmedia\/infographics\/diabetes.html"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104906"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/ME.2014-1410"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220950"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507572102"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.10.005"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020071041"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0009"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410428111"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471488"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1376-0_5"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-008-0019-9"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.6.591"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.190223"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.011"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/614074"},{"key":"e_1_2_5_28_1","first-page":"14","article-title":"Adipose tissue dysfunction in obesity: role of mineralocorticoid receptor","author":"Parasiliti\u2010Caprino M","year":"2022","journal-title":"Nutrients"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7970com"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00280.2020"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-6-90"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90062-T"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200101000-00014"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0292"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2236-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11873"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000202"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2336140100"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.29"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018226"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1999.tb00418.x"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30319-4"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1282-4"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033263"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0819-5"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07806"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-0527-4"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.125"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.022"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr176"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00465-1"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0034-9"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac157"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2022.200138"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00257-3"},{"key":"e_1_2_5_57_1","first-page":"963","article-title":"Mineralocorticoid receptor antagonists and endothelial function","volume":"9","author":"Maron BA","year":"2008","journal-title":"Cur Opin Invest Drugs"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1131290"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.3410"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.028146"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161119666210720120439"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:30:26Z","timestamp":1734550226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jch.14898"],"URL":"https:\/\/doi.org\/10.1111\/jch.14898","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}