{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:32:45Z","timestamp":1791873165779,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors investigated the antihypertensive effect of sacubitril\/valsartan (Sac\/Val) when switching from other drugs and assessed whether brain natriuretic peptide (BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood pressure lowering after switching to Sac\/Val. In 92 patients with treated hypertension, clinic blood pressure, plasma BNP, and PRA were examined before and after switching to Sac\/Val. Clinic systolic and diastolic blood pressures significantly decreased after drug switching to Sac\/Val (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.0001, respectively). The level before drug switching of BNP had no correlation with the change in systolic blood pressure (\u0394\u2010SBP) before and after switching to Sac\/Val, but that of PRA was significantly correlated with \u0394\u2010SBP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.3807, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.0002). A multiple regression analysis revealed that PRA before drug switching was an independent determinant of \u0394\u2010SBP. Our findings suggest that low PRA may become a useful marker to predict the antihypertensive effect of switching to Sac\/Val in treated hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.14900","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:30:05Z","timestamp":1725877805000},"page":"1196-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma renin activity as a marker for predicting the antihypertensive effect of switching to sacubitril\/valsartan in treated hypertensive patients: Usefulness in daily clinical practice"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-737X","authenticated-orcid":false,"given":"Takeshi","family":"Horio","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Ishikiriseiki Hospital  Higashiosaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-7324","authenticated-orcid":false,"given":"Yoshio","family":"Iwashima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kansai Medical University Kori Hospital  Neyagawa Japan"},{"name":"Department of Nephrology and Hypertension Dokkyo Medical University  Mibu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daito Central Hospital  Daito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiju","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatemitsu","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Dokkyo Medical University  Mibu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Ishikiriseiki Hospital  Higashiosaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-483"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-023-00851-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14120"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00706-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00819-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-503"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027612","article-title":"Twenty\u2010four\u2010hour blood pressure\u2010lowering efficacy of sacubitril\/valsartan versus olmesartan in Japanese patients with essential hypertension based on nocturnal blood pressure dipping status: a post hoc analysis of data from a randomized, double\u2010blind multicenter study","volume":"12","author":"Kario K","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08484"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/6.9.780"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14454"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14635"}],"container-title":["The Journal of Clinical 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